DNA Microsystems for Biodiagnosis
Researchers are continuously making progress towards diagnosis and treatment of numerous diseases. However, there are still major issues that are presenting many challenges for current medical diagnosis. On the other hand, DNA nanotechnology has evolved significantly over the last three decades and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/11/4/445 |
| _version_ | 1797569786176077824 |
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| author | Alana Torres Vidal Igor L. Medintz Hieu Bui |
| author_facet | Alana Torres Vidal Igor L. Medintz Hieu Bui |
| author_sort | Alana Torres Vidal |
| collection | DOAJ |
| description | Researchers are continuously making progress towards diagnosis and treatment of numerous diseases. However, there are still major issues that are presenting many challenges for current medical diagnosis. On the other hand, DNA nanotechnology has evolved significantly over the last three decades and is highly interdisciplinary. With many potential technologies derived from the field, it is natural to begin exploring and incorporating its knowledge to develop DNA microsystems for biodiagnosis in order to help address current obstacles, such as disease detection and drug resistance. Here, current challenges in disease detection are presented along with standard methods for diagnosis. Then, a brief overview of DNA nanotechnology is introduced along with its main attractive features for constructing biodiagnostic microsystems. Lastly, suggested DNA-based microsystems are discussed through proof-of-concept demonstrations with improvement strategies for standard diagnostic approaches. |
| first_indexed | 2024-03-10T20:16:29Z |
| format | Article |
| id | doaj.art-82e8571d4669481abd12fc1ded6c2280 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T20:16:29Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-82e8571d4669481abd12fc1ded6c22802023-11-19T22:30:36ZengMDPI AGMicromachines2072-666X2020-04-0111444510.3390/mi11040445DNA Microsystems for BiodiagnosisAlana Torres Vidal0Igor L. Medintz1Hieu Bui2Department of Electrical Engineering and Computer Science, The Catholic University of America, Washington, DC 20064, USACenter for Bio/Molecular Science and Engineering, Code 6900, U.S. Naval Research Laboratory, Washington, DC 20375, USADepartment of Electrical Engineering and Computer Science, The Catholic University of America, Washington, DC 20064, USAResearchers are continuously making progress towards diagnosis and treatment of numerous diseases. However, there are still major issues that are presenting many challenges for current medical diagnosis. On the other hand, DNA nanotechnology has evolved significantly over the last three decades and is highly interdisciplinary. With many potential technologies derived from the field, it is natural to begin exploring and incorporating its knowledge to develop DNA microsystems for biodiagnosis in order to help address current obstacles, such as disease detection and drug resistance. Here, current challenges in disease detection are presented along with standard methods for diagnosis. Then, a brief overview of DNA nanotechnology is introduced along with its main attractive features for constructing biodiagnostic microsystems. Lastly, suggested DNA-based microsystems are discussed through proof-of-concept demonstrations with improvement strategies for standard diagnostic approaches.https://www.mdpi.com/2072-666X/11/4/445diagnosisDNA nanotechnologyDNA-based medicinenucleic acids |
| spellingShingle | Alana Torres Vidal Igor L. Medintz Hieu Bui DNA Microsystems for Biodiagnosis Micromachines diagnosis DNA nanotechnology DNA-based medicine nucleic acids |
| title | DNA Microsystems for Biodiagnosis |
| title_full | DNA Microsystems for Biodiagnosis |
| title_fullStr | DNA Microsystems for Biodiagnosis |
| title_full_unstemmed | DNA Microsystems for Biodiagnosis |
| title_short | DNA Microsystems for Biodiagnosis |
| title_sort | dna microsystems for biodiagnosis |
| topic | diagnosis DNA nanotechnology DNA-based medicine nucleic acids |
| url | https://www.mdpi.com/2072-666X/11/4/445 |
| work_keys_str_mv | AT alanatorresvidal dnamicrosystemsforbiodiagnosis AT igorlmedintz dnamicrosystemsforbiodiagnosis AT hieubui dnamicrosystemsforbiodiagnosis |