Structural basis for Ccd1 auto-inhibition in the Wnt pathway through homomerization of the DIX domain

Structural basis for Ccd1 auto-inhibition in the Wnt pathway through homomerization of the DIX domain

Abstract Wnt signaling plays an important role in governing cell fate decisions. Coiled-coil-DIX1 (Ccd1), Dishevelled (Dvl), and Axin are signaling proteins that regulate the canonical pathway by controlling the stability of a key signal transducer β-catenin. These proteins contain the DIX domain wi...

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Bibliographic Details
Main Authors: Shin-ichi Terawaki, Shohei Fujita, Takuya Katsutani, Kensuke Shiomi, Kazuko Keino-Masu, Masayuki Masu, Kaori Wakamatsu, Naoki Shibata, Yoshiki Higuchi
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08019-5

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