The Effect of Alendronate on Osteoclastogenesis in Different Combinations of M-CSF and RANKL Growth Factors

The Effect of Alendronate on Osteoclastogenesis in Different Combinations of M-CSF and RANKL Growth Factors

Bisphosphonates (BPs) are compounds resembling the pyrophosphate structure. BPs bind the mineral component of bones. During the bone resorption by osteoclasts, nitrogen-containing BPs are released and internalized, causing an inhibition of the mevalonate pathway. As a consequence, osteoclasts are un...

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Bibliographic Details
Main Authors: Věra Hedvičáková, Radmila Žižková, Matěj Buzgo, Michala Rampichová, Eva Filová
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Biomolecules
Subjects:
alendronate
M-CSF
osteoclastogenesis
RANKL
Online Access:https://www.mdpi.com/2218-273X/11/3/438

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