New Parametric Imaging Method with Fluorescein Angiograms for Detecting Areas of Capillary Nonperfusion
ObjectivesFluorescein angiography (FAG) is currently the most useful diagnostic modality for examining retinal circulation, and it is frequently used for the evaluation of patients with diabetic retinopathy, occlusive diseases, such as retinal venous and arterial occlusions, and wet macular degenera...
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| Format: | Article |
| Language: | English |
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The Korean Society of Medical Informatics
2014-07-01
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| Series: | Healthcare Informatics Research |
| Subjects: | |
| Online Access: | http://e-hir.org/upload/pdf/hir-20-191.pdf |
| _version_ | 1819003683619209216 |
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| author | Young Jae Kim Chang Bu Jeong Jeong-Min Hwang Hee Kyung Yang Seung Hyun Lee Kwang Gi Kim |
| author_facet | Young Jae Kim Chang Bu Jeong Jeong-Min Hwang Hee Kyung Yang Seung Hyun Lee Kwang Gi Kim |
| author_sort | Young Jae Kim |
| collection | DOAJ |
| description | ObjectivesFluorescein angiography (FAG) is currently the most useful diagnostic modality for examining retinal circulation, and it is frequently used for the evaluation of patients with diabetic retinopathy, occlusive diseases, such as retinal venous and arterial occlusions, and wet macular degeneration. This paper presents a method for objectively evaluating retinal circulation by quantifying circulation-related parameters.MethodsThis method allows the semiautomatic preprocessing and registering of FAG images. The arterial input function is estimated from the registered set of FAG images using gamma-variate fitting. Then, the parameters can be computed by deconvolution on the basis of truncated singular value decomposition, and they can finally be presented as parametric color images in a combination of three colors, red, green, and blue.ResultsAfter the estimation of arterial input function, the parameters of relative blood flow and mean transit time were computed using deconvolution analysis based on truncated singular value decomposition.ConclusionsThe parametric color image is helpful to interpret the status of retinal blood circulation and provides quantitative data on retina ischemia without interobserver variability. This system easily provides the status of retinal blood circulation both qualitatively and quantitatively. It also helps to standardize FAG interpretation and may contribute to network-based telemedicine systems in the future. |
| first_indexed | 2024-12-20T23:24:54Z |
| format | Article |
| id | doaj.art-82eb7e2e45394865b391601f0dc5f910 |
| institution | Directory Open Access Journal |
| issn | 2093-3681 2093-369X |
| language | English |
| last_indexed | 2024-12-20T23:24:54Z |
| publishDate | 2014-07-01 |
| publisher | The Korean Society of Medical Informatics |
| record_format | Article |
| series | Healthcare Informatics Research |
| spelling | doaj.art-82eb7e2e45394865b391601f0dc5f9102022-12-21T19:23:25ZengThe Korean Society of Medical InformaticsHealthcare Informatics Research2093-36812093-369X2014-07-0120319119810.4258/hir.2014.20.3.191733New Parametric Imaging Method with Fluorescein Angiograms for Detecting Areas of Capillary NonperfusionYoung Jae Kim0Chang Bu Jeong1Jeong-Min Hwang2Hee Kyung Yang3Seung Hyun Lee4Kwang Gi Kim5Biomedical Engineering Branch, Division of Convergence Technology, Research Institute, National Cancer Center, Goyang, Korea.Biomedical Engineering Branch, Division of Convergence Technology, Research Institute, National Cancer Center, Goyang, Korea.Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.Department of Plasma Bio Display, Kwangwoon Universiy, Seoul, Korea.Biomedical Engineering Branch, Division of Convergence Technology, Research Institute, National Cancer Center, Goyang, Korea.ObjectivesFluorescein angiography (FAG) is currently the most useful diagnostic modality for examining retinal circulation, and it is frequently used for the evaluation of patients with diabetic retinopathy, occlusive diseases, such as retinal venous and arterial occlusions, and wet macular degeneration. This paper presents a method for objectively evaluating retinal circulation by quantifying circulation-related parameters.MethodsThis method allows the semiautomatic preprocessing and registering of FAG images. The arterial input function is estimated from the registered set of FAG images using gamma-variate fitting. Then, the parameters can be computed by deconvolution on the basis of truncated singular value decomposition, and they can finally be presented as parametric color images in a combination of three colors, red, green, and blue.ResultsAfter the estimation of arterial input function, the parameters of relative blood flow and mean transit time were computed using deconvolution analysis based on truncated singular value decomposition.ConclusionsThe parametric color image is helpful to interpret the status of retinal blood circulation and provides quantitative data on retina ischemia without interobserver variability. This system easily provides the status of retinal blood circulation both qualitatively and quantitatively. It also helps to standardize FAG interpretation and may contribute to network-based telemedicine systems in the future.http://e-hir.org/upload/pdf/hir-20-191.pdffluorescein angiographyophthalmologyeye diseasecomputer-assisted diagnosisbiomedical engineering |
| spellingShingle | Young Jae Kim Chang Bu Jeong Jeong-Min Hwang Hee Kyung Yang Seung Hyun Lee Kwang Gi Kim New Parametric Imaging Method with Fluorescein Angiograms for Detecting Areas of Capillary Nonperfusion Healthcare Informatics Research fluorescein angiography ophthalmology eye disease computer-assisted diagnosis biomedical engineering |
| title | New Parametric Imaging Method with Fluorescein Angiograms for Detecting Areas of Capillary Nonperfusion |
| title_full | New Parametric Imaging Method with Fluorescein Angiograms for Detecting Areas of Capillary Nonperfusion |
| title_fullStr | New Parametric Imaging Method with Fluorescein Angiograms for Detecting Areas of Capillary Nonperfusion |
| title_full_unstemmed | New Parametric Imaging Method with Fluorescein Angiograms for Detecting Areas of Capillary Nonperfusion |
| title_short | New Parametric Imaging Method with Fluorescein Angiograms for Detecting Areas of Capillary Nonperfusion |
| title_sort | new parametric imaging method with fluorescein angiograms for detecting areas of capillary nonperfusion |
| topic | fluorescein angiography ophthalmology eye disease computer-assisted diagnosis biomedical engineering |
| url | http://e-hir.org/upload/pdf/hir-20-191.pdf |
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