Increasing Antimicrobial Resistance in Surgical Wards at Mulago National Referral Hospital, Uganda, from 2014 to 2018—Cause for Concern?
Antimicrobial Resistance (AMR) and Healthcare Associated Infections (HAIs) are major global public health challenges in our time. This study provides a broader and updated overview of AMR trends in surgical wards of Mulago National Referral Hospital (MNRH) between 2014 and 2018. Laboratory data on t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/6/2/82 |
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| author | Gerald Mboowa Dickson Aruhomukama Ivan Sserwadda Freddy Eric Kitutu Hayk Davtyan Philip Owiti Edward Mberu Kamau Wendemagegn Enbiale Anthony Reid Douglas Bulafu Jeffrey Kisukye Margaret Lubwama Henry Kajumbula |
| author_facet | Gerald Mboowa Dickson Aruhomukama Ivan Sserwadda Freddy Eric Kitutu Hayk Davtyan Philip Owiti Edward Mberu Kamau Wendemagegn Enbiale Anthony Reid Douglas Bulafu Jeffrey Kisukye Margaret Lubwama Henry Kajumbula |
| author_sort | Gerald Mboowa |
| collection | DOAJ |
| description | Antimicrobial Resistance (AMR) and Healthcare Associated Infections (HAIs) are major global public health challenges in our time. This study provides a broader and updated overview of AMR trends in surgical wards of Mulago National Referral Hospital (MNRH) between 2014 and 2018. Laboratory data on the antimicrobial susceptibility profiles of bacterial isolates from 428 patient samples were available. The most common samples were as follows: tracheal aspirates (36.5%), pus swabs (28.0%), and blood (20.6%). Klebsiella (21.7%), Acinetobacter (17.5%), and Staphylococcus species (12.4%) were the most common isolates. The resistance patterns for different antimicrobials were: penicillins (40–100%), cephalosporins (30–100%), <i>β</i>-lactamase inhibitor combinations (70–100%), carbapenems (10–100%), polymyxin E (0–7%), aminoglycosides (50–100%), sulphonamides (80–100%), fluoroquinolones (40–70%), macrolides (40–100%), lincosamides (10–45%), phenicols (40–70%), nitrofurans (0–25%), and glycopeptide (0–20%). This study demonstrated a sustained increase in resistance among the most commonly used antibiotics in Uganda over the five-year study period. It implies ongoing hospital-based monitoring and surveillance of AMR patterns are needed to inform antibiotic prescribing, and to contribute to national and global AMR profiles. It also suggests continued emphasis on infection prevention and control practices (IPC), including antibiotic stewardship. Ultimately, laboratory capacity for timely bacteriological culture and sensitivity testing will provide a rational choice of antibiotics for HAI. |
| first_indexed | 2024-03-10T11:17:11Z |
| format | Article |
| id | doaj.art-82ed53d65e224d488489f5c41e928a44 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-10T11:17:11Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-82ed53d65e224d488489f5c41e928a442023-11-21T20:21:03ZengMDPI AGTropical Medicine and Infectious Disease2414-63662021-05-01628210.3390/tropicalmed6020082Increasing Antimicrobial Resistance in Surgical Wards at Mulago National Referral Hospital, Uganda, from 2014 to 2018—Cause for Concern?Gerald Mboowa0Dickson Aruhomukama1Ivan Sserwadda2Freddy Eric Kitutu3Hayk Davtyan4Philip Owiti5Edward Mberu Kamau6Wendemagegn Enbiale7Anthony Reid8Douglas Bulafu9Jeffrey Kisukye10Margaret Lubwama11Henry Kajumbula12The African Center of Excellence in Bioinformatics and Data-Intensive Sciences, The Infectious Diseases Institute, Makerere University, Kampala P.O. Box 22418, UgandaDepartment of Immunology and Molecular Biology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, UgandaDepartment of Immunology and Molecular Biology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, UgandaStrengthening Pharmaceutical Systems (SPS) Unit, Pharmacy Department, School of Health Sciences, Makerere University, Kampala P.O. Box 7072, UgandaTuberculosis Research and Prevention Center NGO, Yerevan 0014, ArmeniaAcademic Model Providing Access to Healthcare (AMPATH), P.O. Box 9505, Eldoret 30100, KenyaResearch Capacity Strengthening, Special Programme for Research and Training in Tropical Diseases, 1201 Geneva, SwitzerlandDepartment of Dermatovenerology, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar P.O. Box 1996, EthiopiaMédecins Sans Frontières, Operational Centre Brussels, Operational Research Unit, 1617 Luxembourg, LuxembourgDepartment of Environmental Health Sciences, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, UgandaDepartment of Medical Microbiology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, UgandaDepartment of Medical Microbiology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, UgandaDepartment of Medical Microbiology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, UgandaAntimicrobial Resistance (AMR) and Healthcare Associated Infections (HAIs) are major global public health challenges in our time. This study provides a broader and updated overview of AMR trends in surgical wards of Mulago National Referral Hospital (MNRH) between 2014 and 2018. Laboratory data on the antimicrobial susceptibility profiles of bacterial isolates from 428 patient samples were available. The most common samples were as follows: tracheal aspirates (36.5%), pus swabs (28.0%), and blood (20.6%). Klebsiella (21.7%), Acinetobacter (17.5%), and Staphylococcus species (12.4%) were the most common isolates. The resistance patterns for different antimicrobials were: penicillins (40–100%), cephalosporins (30–100%), <i>β</i>-lactamase inhibitor combinations (70–100%), carbapenems (10–100%), polymyxin E (0–7%), aminoglycosides (50–100%), sulphonamides (80–100%), fluoroquinolones (40–70%), macrolides (40–100%), lincosamides (10–45%), phenicols (40–70%), nitrofurans (0–25%), and glycopeptide (0–20%). This study demonstrated a sustained increase in resistance among the most commonly used antibiotics in Uganda over the five-year study period. It implies ongoing hospital-based monitoring and surveillance of AMR patterns are needed to inform antibiotic prescribing, and to contribute to national and global AMR profiles. It also suggests continued emphasis on infection prevention and control practices (IPC), including antibiotic stewardship. Ultimately, laboratory capacity for timely bacteriological culture and sensitivity testing will provide a rational choice of antibiotics for HAI.https://www.mdpi.com/2414-6366/6/2/82antimicrobial resistance (AMR)trendsStructured Operational Research and Training IniTiative (SORT IT)surgical wardsMulago National Referral Hospital (MNRH)Uganda |
| spellingShingle | Gerald Mboowa Dickson Aruhomukama Ivan Sserwadda Freddy Eric Kitutu Hayk Davtyan Philip Owiti Edward Mberu Kamau Wendemagegn Enbiale Anthony Reid Douglas Bulafu Jeffrey Kisukye Margaret Lubwama Henry Kajumbula Increasing Antimicrobial Resistance in Surgical Wards at Mulago National Referral Hospital, Uganda, from 2014 to 2018—Cause for Concern? Tropical Medicine and Infectious Disease antimicrobial resistance (AMR) trends Structured Operational Research and Training IniTiative (SORT IT) surgical wards Mulago National Referral Hospital (MNRH) Uganda |
| title | Increasing Antimicrobial Resistance in Surgical Wards at Mulago National Referral Hospital, Uganda, from 2014 to 2018—Cause for Concern? |
| title_full | Increasing Antimicrobial Resistance in Surgical Wards at Mulago National Referral Hospital, Uganda, from 2014 to 2018—Cause for Concern? |
| title_fullStr | Increasing Antimicrobial Resistance in Surgical Wards at Mulago National Referral Hospital, Uganda, from 2014 to 2018—Cause for Concern? |
| title_full_unstemmed | Increasing Antimicrobial Resistance in Surgical Wards at Mulago National Referral Hospital, Uganda, from 2014 to 2018—Cause for Concern? |
| title_short | Increasing Antimicrobial Resistance in Surgical Wards at Mulago National Referral Hospital, Uganda, from 2014 to 2018—Cause for Concern? |
| title_sort | increasing antimicrobial resistance in surgical wards at mulago national referral hospital uganda from 2014 to 2018 cause for concern |
| topic | antimicrobial resistance (AMR) trends Structured Operational Research and Training IniTiative (SORT IT) surgical wards Mulago National Referral Hospital (MNRH) Uganda |
| url | https://www.mdpi.com/2414-6366/6/2/82 |
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