SSRI and Motor Recovery in Stroke: Reestablishment of Inhibitory Neural Network Tonus
Selective serotonin reuptake inhibitors (SSRIs) are currently widely used in the field of the neuromodulation not only because of their anti-depressive effects but also due to their ability to promote plasticity and enhance motor recovery in patients with stroke. Recent studies showed that fluoxetin...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnins.2017.00637/full |
| _version_ | 1818253827970695168 |
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| author | Camila B. Pinto Camila B. Pinto Faddi G. Saleh Velez Fernanda Lopes Polyana V. de Toledo Piza Polyana V. de Toledo Piza Laura Dipietro Qing M. Wang Nicole L. Mazwi Erica C. Camargo Randie Black-Schaffer Felipe Fregni |
| author_facet | Camila B. Pinto Camila B. Pinto Faddi G. Saleh Velez Fernanda Lopes Polyana V. de Toledo Piza Polyana V. de Toledo Piza Laura Dipietro Qing M. Wang Nicole L. Mazwi Erica C. Camargo Randie Black-Schaffer Felipe Fregni |
| author_sort | Camila B. Pinto |
| collection | DOAJ |
| description | Selective serotonin reuptake inhibitors (SSRIs) are currently widely used in the field of the neuromodulation not only because of their anti-depressive effects but also due to their ability to promote plasticity and enhance motor recovery in patients with stroke. Recent studies showed that fluoxetine promotes motor recovery after stroke through its effects on the serotonergic system enhancing motor outputs and facilitating long term potentiation, key factors in motor neural plasticity. However, little is known in regards of the exact mechanisms underlying these effects and several aspects of it remain poorly understood. In this manuscript, we discuss evidence supporting the hypothesis that SSRIs, and in particular fluoxetine, modulate inhibitory pathways, and that this modulation enhances reorganization and reestablishment of excitatory-inhibitory control; these effects play a key role in learning induced plasticity in neural circuits involved in the promotion of motor recovery after stroke. This discussion aims to provide important insights and rationale for the development of novel strategies for stroke motor rehabilitation. |
| first_indexed | 2024-12-12T16:46:16Z |
| format | Article |
| id | doaj.art-82edae3713754171a5df6cfccab5bec9 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-12T16:46:16Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-82edae3713754171a5df6cfccab5bec92022-12-22T00:18:28ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2017-11-011110.3389/fnins.2017.00637280501SSRI and Motor Recovery in Stroke: Reestablishment of Inhibitory Neural Network TonusCamila B. Pinto0Camila B. Pinto1Faddi G. Saleh Velez2Fernanda Lopes3Polyana V. de Toledo Piza4Polyana V. de Toledo Piza5Laura Dipietro6Qing M. Wang7Nicole L. Mazwi8Erica C. Camargo9Randie Black-Schaffer10Felipe Fregni11Laboratory of Neuromodulation and Center for Clinical Research Learning, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Harvard University, Boston, MA, United StatesDepartment of Neuroscience and Behavior, Psychology Institute, University of São Paulo, São Paulo, BrazilLaboratory of Neuromodulation and Center for Clinical Research Learning, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Harvard University, Boston, MA, United StatesLaboratory of Neuromodulation and Center for Clinical Research Learning, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Harvard University, Boston, MA, United StatesLaboratory of Neuromodulation and Center for Clinical Research Learning, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Harvard University, Boston, MA, United StatesDepartment of Severe Patients, Hospital Israelita Albert Einstein, São Paulo, BrazilHighland Instruments, Cambridge, MA, United StatesStroke Biological Recovery Laboratory, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Harvard University, Boston, MA, United StatesDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Harvard University, Boston, MA, United StatesDepartment of Neurology, Harvard Medical School, Massachusetts General Hospital, Harvard University, Boston, MA, United StatesDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Harvard University, Boston, MA, United StatesLaboratory of Neuromodulation and Center for Clinical Research Learning, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Harvard University, Boston, MA, United StatesSelective serotonin reuptake inhibitors (SSRIs) are currently widely used in the field of the neuromodulation not only because of their anti-depressive effects but also due to their ability to promote plasticity and enhance motor recovery in patients with stroke. Recent studies showed that fluoxetine promotes motor recovery after stroke through its effects on the serotonergic system enhancing motor outputs and facilitating long term potentiation, key factors in motor neural plasticity. However, little is known in regards of the exact mechanisms underlying these effects and several aspects of it remain poorly understood. In this manuscript, we discuss evidence supporting the hypothesis that SSRIs, and in particular fluoxetine, modulate inhibitory pathways, and that this modulation enhances reorganization and reestablishment of excitatory-inhibitory control; these effects play a key role in learning induced plasticity in neural circuits involved in the promotion of motor recovery after stroke. This discussion aims to provide important insights and rationale for the development of novel strategies for stroke motor rehabilitation.http://journal.frontiersin.org/article/10.3389/fnins.2017.00637/fullstrokemotor rehabilitationSSRIscortical excitabilityinhibitory tonusneuroplasticity |
| spellingShingle | Camila B. Pinto Camila B. Pinto Faddi G. Saleh Velez Fernanda Lopes Polyana V. de Toledo Piza Polyana V. de Toledo Piza Laura Dipietro Qing M. Wang Nicole L. Mazwi Erica C. Camargo Randie Black-Schaffer Felipe Fregni SSRI and Motor Recovery in Stroke: Reestablishment of Inhibitory Neural Network Tonus Frontiers in Neuroscience stroke motor rehabilitation SSRIs cortical excitability inhibitory tonus neuroplasticity |
| title | SSRI and Motor Recovery in Stroke: Reestablishment of Inhibitory Neural Network Tonus |
| title_full | SSRI and Motor Recovery in Stroke: Reestablishment of Inhibitory Neural Network Tonus |
| title_fullStr | SSRI and Motor Recovery in Stroke: Reestablishment of Inhibitory Neural Network Tonus |
| title_full_unstemmed | SSRI and Motor Recovery in Stroke: Reestablishment of Inhibitory Neural Network Tonus |
| title_short | SSRI and Motor Recovery in Stroke: Reestablishment of Inhibitory Neural Network Tonus |
| title_sort | ssri and motor recovery in stroke reestablishment of inhibitory neural network tonus |
| topic | stroke motor rehabilitation SSRIs cortical excitability inhibitory tonus neuroplasticity |
| url | http://journal.frontiersin.org/article/10.3389/fnins.2017.00637/full |
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