Inhibitory Effect of b-AP15 on the 20S Proteasome
The 26S proteasome is a cellular proteolytic complex containing 19S regulatory particles and the 20S core proteasome. It was reported that the small molecule b-AP15 targets the proteasome by inhibiting deubiquitination of the 19S regulatory particles of the proteasome complex. An investigation of b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-10-01
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| Series: | Biomolecules |
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| Online Access: | http://www.mdpi.com/2218-273X/4/4/931 |
| _version_ | 1811258980925702144 |
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| author | Li Huang Katherine Jung Chin Ho Chen |
| author_facet | Li Huang Katherine Jung Chin Ho Chen |
| author_sort | Li Huang |
| collection | DOAJ |
| description | The 26S proteasome is a cellular proteolytic complex containing 19S regulatory particles and the 20S core proteasome. It was reported that the small molecule b-AP15 targets the proteasome by inhibiting deubiquitination of the 19S regulatory particles of the proteasome complex. An investigation of b-AP15 on the 20S proteasome core suggested that this compound can also inhibit the 20S proteasome with a potency equivalent to that found to inhibit the 19S regulatory particles. |
| first_indexed | 2024-04-12T18:22:40Z |
| format | Article |
| id | doaj.art-82ee02c63c9243a2919f61acbd0d11c7 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-04-12T18:22:40Z |
| publishDate | 2014-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-82ee02c63c9243a2919f61acbd0d11c72022-12-22T03:21:22ZengMDPI AGBiomolecules2218-273X2014-10-014493193910.3390/biom4040931biom4040931Inhibitory Effect of b-AP15 on the 20S ProteasomeLi Huang0Katherine Jung1Chin Ho Chen2Department of Surgery, Duke University Medical Center, Durham, NC 27710, USADepartment of Surgery, Duke University Medical Center, Durham, NC 27710, USADepartment of Surgery, Duke University Medical Center, Durham, NC 27710, USAThe 26S proteasome is a cellular proteolytic complex containing 19S regulatory particles and the 20S core proteasome. It was reported that the small molecule b-AP15 targets the proteasome by inhibiting deubiquitination of the 19S regulatory particles of the proteasome complex. An investigation of b-AP15 on the 20S proteasome core suggested that this compound can also inhibit the 20S proteasome with a potency equivalent to that found to inhibit the 19S regulatory particles.http://www.mdpi.com/2218-273X/4/4/931proteasome inhibitorb-AP1519S regulatory particles |
| spellingShingle | Li Huang Katherine Jung Chin Ho Chen Inhibitory Effect of b-AP15 on the 20S Proteasome Biomolecules proteasome inhibitor b-AP15 19S regulatory particles |
| title | Inhibitory Effect of b-AP15 on the 20S Proteasome |
| title_full | Inhibitory Effect of b-AP15 on the 20S Proteasome |
| title_fullStr | Inhibitory Effect of b-AP15 on the 20S Proteasome |
| title_full_unstemmed | Inhibitory Effect of b-AP15 on the 20S Proteasome |
| title_short | Inhibitory Effect of b-AP15 on the 20S Proteasome |
| title_sort | inhibitory effect of b ap15 on the 20s proteasome |
| topic | proteasome inhibitor b-AP15 19S regulatory particles |
| url | http://www.mdpi.com/2218-273X/4/4/931 |
| work_keys_str_mv | AT lihuang inhibitoryeffectofbap15onthe20sproteasome AT katherinejung inhibitoryeffectofbap15onthe20sproteasome AT chinhochen inhibitoryeffectofbap15onthe20sproteasome |