Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum
Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O–S (1–5) and a new “monomeric” cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-11-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/8/11/2837/ |
| _version_ | 1798041733110431744 |
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| author | Wenhan Lin Pengcheng Yan Leen van Ofwegen Zhiwei Deng Peter Proksch |
| author_facet | Wenhan Lin Pengcheng Yan Leen van Ofwegen Zhiwei Deng Peter Proksch |
| author_sort | Wenhan Lin |
| collection | DOAJ |
| description | Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O–S (1–5) and a new “monomeric” cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic data in association with MS and IR data. Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophages, while lobophytones Q and T showed inhibitory activities against the bacteria S. aureus and S. pneumoniae. |
| first_indexed | 2024-04-11T22:25:38Z |
| format | Article |
| id | doaj.art-82ee17949bcd4d7196dc2fcf839b2902 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T22:25:38Z |
| publishDate | 2010-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-82ee17949bcd4d7196dc2fcf839b29022022-12-22T03:59:43ZengMDPI AGMarine Drugs1660-33972010-11-018112837284810.3390/md8112848Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorumWenhan LinPengcheng YanLeen van OfwegenZhiwei DengPeter ProkschChemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O–S (1–5) and a new “monomeric” cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic data in association with MS and IR data. Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophages, while lobophytones Q and T showed inhibitory activities against the bacteria S. aureus and S. pneumoniae.http://www.mdpi.com/1660-3397/8/11/2837/soft coralLobophytum pauciflorumlobophytones O–Tstructure elucidationNO inhibitionantibiotic activity |
| spellingShingle | Wenhan Lin Pengcheng Yan Leen van Ofwegen Zhiwei Deng Peter Proksch Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum Marine Drugs soft coral Lobophytum pauciflorum lobophytones O–T structure elucidation NO inhibition antibiotic activity |
| title | Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum |
| title_full | Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum |
| title_fullStr | Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum |
| title_full_unstemmed | Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum |
| title_short | Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum |
| title_sort | lobophytones o t new biscembranoids and cembranoid from soft coral lobophytum pauciflorum |
| topic | soft coral Lobophytum pauciflorum lobophytones O–T structure elucidation NO inhibition antibiotic activity |
| url | http://www.mdpi.com/1660-3397/8/11/2837/ |
| work_keys_str_mv | AT wenhanlin lobophytonesotnewbiscembranoidsandcembranoidfromsoftcorallobophytumpauciflorum AT pengchengyan lobophytonesotnewbiscembranoidsandcembranoidfromsoftcorallobophytumpauciflorum AT leenvanofwegen lobophytonesotnewbiscembranoidsandcembranoidfromsoftcorallobophytumpauciflorum AT zhiweideng lobophytonesotnewbiscembranoidsandcembranoidfromsoftcorallobophytumpauciflorum AT peterproksch lobophytonesotnewbiscembranoidsandcembranoidfromsoftcorallobophytumpauciflorum |