Trichotillomania comorbidity in a sample enriched for familial obsessive-compulsive disorder
Background: This study addresses the strength of associations between trichotillomania (TTM) and other DSM-IV Axis I conditions in a large sample (n = 2606) enriched for familial obsessive-compulsive disorder (OCD), to inform TTM classification. Methods: We identified participants with TTM in the Jo...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-10-01
|
| Series: | Comprehensive Psychiatry |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0010440X1930046X |
| _version_ | 1819123730358468608 |
|---|---|
| author | Ted Avi Gerstenblith Ashley Jaramillo-Huff Tuua Ruutiainen Paul S. Nestadt Jack F. Samuels Marco A. Grados Bernadette A. Cullen Mark A. Riddle Kung-Yee Liang Benjamin D. Greenberg Steven A. Rasmussen Scott L. Rauch James T. McCracken John Piacentini James A. Knowles Gerald Nestadt O. Joseph Bienvenu |
| author_facet | Ted Avi Gerstenblith Ashley Jaramillo-Huff Tuua Ruutiainen Paul S. Nestadt Jack F. Samuels Marco A. Grados Bernadette A. Cullen Mark A. Riddle Kung-Yee Liang Benjamin D. Greenberg Steven A. Rasmussen Scott L. Rauch James T. McCracken John Piacentini James A. Knowles Gerald Nestadt O. Joseph Bienvenu |
| author_sort | Ted Avi Gerstenblith |
| collection | DOAJ |
| description | Background: This study addresses the strength of associations between trichotillomania (TTM) and other DSM-IV Axis I conditions in a large sample (n = 2606) enriched for familial obsessive-compulsive disorder (OCD), to inform TTM classification. Methods: We identified participants with TTM in the Johns Hopkins OCD Family Study (153 families) and the OCD Collaborative Genetics Study, a six-site genetic linkage study of OCD (487 families). We used logistic regression (with generalized estimating equations) to assess the strength of associations between TTM and other DSM-IV disorders. Results: TTM had excess comorbidity with a number of conditions from different DSM-IV chapters, including tic disorders, alcohol dependence, mood disorders, anxiety disorders, impulse-control disorders, and bulimia nervosa. However, association strengths (odds ratios) were highest for kleptomania (6.6), pyromania (5.8), OCD (5.6), skin picking disorder (4.4), bulimia nervosa (3.5), and pathological nail biting (3.4). Conclusions: TTM is comorbid with a number of psychiatric conditions besides OCD, and it is strongly associated with other conditions involving impaired impulse control. Though DSM-5 includes TTM as an OCD-related disorder, its comorbidity pattern also emphasizes the impulsive, appetitive aspects of this condition that may be relevant to classification. Keywords: Comorbidity, classification, Impulse-control disorder, Obsessive-compulsive disorder, Trichotillomania |
| first_indexed | 2024-12-22T07:12:59Z |
| format | Article |
| id | doaj.art-82ee5e7684d54fe99a965788e7c5095a |
| institution | Directory Open Access Journal |
| issn | 0010-440X |
| language | English |
| last_indexed | 2024-12-22T07:12:59Z |
| publishDate | 2019-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Comprehensive Psychiatry |
| spelling | doaj.art-82ee5e7684d54fe99a965788e7c5095a2022-12-21T18:34:27ZengElsevierComprehensive Psychiatry0010-440X2019-10-0194Trichotillomania comorbidity in a sample enriched for familial obsessive-compulsive disorderTed Avi Gerstenblith0Ashley Jaramillo-Huff1Tuua Ruutiainen2Paul S. Nestadt3Jack F. Samuels4Marco A. Grados5Bernadette A. Cullen6Mark A. Riddle7Kung-Yee Liang8Benjamin D. Greenberg9Steven A. Rasmussen10Scott L. Rauch11James T. McCracken12John Piacentini13James A. Knowles14Gerald Nestadt15O. Joseph Bienvenu16Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of AmericaUniversity of New Mexico School of Medicine, Department of Obstetrics and Gynecology, United States of AmericaUniversity of Pennsylvania Perelman School of Medicine, Department of Psychiatry, United States of AmericaJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of AmericaJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of AmericaJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of AmericaJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of AmericaJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of AmericaNational Yang-Ming University, TaiwanBrown Medical School, Department of Psychiatry and Human Behavior, United States of AmericaBrown Medical School, Department of Psychiatry and Human Behavior, United States of AmericaHarvard Medical School, Department of Psychiatry, United States of AmericaUniversity of California, Los Angeles School of Medicine, Department of Psychiatry and Biobehavioral Sciences, United States of AmericaUniversity of California, Los Angeles School of Medicine, Department of Psychiatry and Biobehavioral Sciences, United States of AmericaSUNY Downstate Medical Center College of Medicine, Department of Cell Biology, United States of AmericaJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of AmericaJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of America; Corresponding author at: Johns Hopkins University, 600 N. Wolfe St. – Meyer 115, Baltimore, MD 21287, United States of America.Background: This study addresses the strength of associations between trichotillomania (TTM) and other DSM-IV Axis I conditions in a large sample (n = 2606) enriched for familial obsessive-compulsive disorder (OCD), to inform TTM classification. Methods: We identified participants with TTM in the Johns Hopkins OCD Family Study (153 families) and the OCD Collaborative Genetics Study, a six-site genetic linkage study of OCD (487 families). We used logistic regression (with generalized estimating equations) to assess the strength of associations between TTM and other DSM-IV disorders. Results: TTM had excess comorbidity with a number of conditions from different DSM-IV chapters, including tic disorders, alcohol dependence, mood disorders, anxiety disorders, impulse-control disorders, and bulimia nervosa. However, association strengths (odds ratios) were highest for kleptomania (6.6), pyromania (5.8), OCD (5.6), skin picking disorder (4.4), bulimia nervosa (3.5), and pathological nail biting (3.4). Conclusions: TTM is comorbid with a number of psychiatric conditions besides OCD, and it is strongly associated with other conditions involving impaired impulse control. Though DSM-5 includes TTM as an OCD-related disorder, its comorbidity pattern also emphasizes the impulsive, appetitive aspects of this condition that may be relevant to classification. Keywords: Comorbidity, classification, Impulse-control disorder, Obsessive-compulsive disorder, Trichotillomaniahttp://www.sciencedirect.com/science/article/pii/S0010440X1930046X |
| spellingShingle | Ted Avi Gerstenblith Ashley Jaramillo-Huff Tuua Ruutiainen Paul S. Nestadt Jack F. Samuels Marco A. Grados Bernadette A. Cullen Mark A. Riddle Kung-Yee Liang Benjamin D. Greenberg Steven A. Rasmussen Scott L. Rauch James T. McCracken John Piacentini James A. Knowles Gerald Nestadt O. Joseph Bienvenu Trichotillomania comorbidity in a sample enriched for familial obsessive-compulsive disorder Comprehensive Psychiatry |
| title | Trichotillomania comorbidity in a sample enriched for familial obsessive-compulsive disorder |
| title_full | Trichotillomania comorbidity in a sample enriched for familial obsessive-compulsive disorder |
| title_fullStr | Trichotillomania comorbidity in a sample enriched for familial obsessive-compulsive disorder |
| title_full_unstemmed | Trichotillomania comorbidity in a sample enriched for familial obsessive-compulsive disorder |
| title_short | Trichotillomania comorbidity in a sample enriched for familial obsessive-compulsive disorder |
| title_sort | trichotillomania comorbidity in a sample enriched for familial obsessive compulsive disorder |
| url | http://www.sciencedirect.com/science/article/pii/S0010440X1930046X |
| work_keys_str_mv | AT tedavigerstenblith trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT ashleyjaramillohuff trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT tuuaruutiainen trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT paulsnestadt trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT jackfsamuels trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT marcoagrados trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT bernadetteacullen trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT markariddle trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT kungyeeliang trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT benjamindgreenberg trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT stevenarasmussen trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT scottlrauch trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT jamestmccracken trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT johnpiacentini trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT jamesaknowles trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT geraldnestadt trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder AT ojosephbienvenu trichotillomaniacomorbidityinasampleenrichedforfamilialobsessivecompulsivedisorder |