Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

Abstract Background Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson’s disease (PD). Elevated kinase activity is associated with LRRK2 toxicity, but the substrates that mediate neurodegeneration remain poorly defined. Given the increasing...

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Main Authors: Ga Ram Jeong, Eun-Hae Jang, Jae Ryul Bae, Soyoung Jun, Ho Chul Kang, Chi-Hu Park, Joo-Ho Shin, Yukio Yamamoto, Keiko Tanaka-Yamamoto, Valina L. Dawson, Ted M. Dawson, Eun-Mi Hur, Byoung Dae Lee
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Neurodegeneration
Subjects:
LRRK2
Rab GTPases
Phosphorylation
Neurodegeneration
Parkinson’s disease
Online Access:http://link.springer.com/article/10.1186/s13024-018-0240-1

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