Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders
Abstract Most research on fluid biomarkers for central nervous system (CNS) disorders has so far been performed using cerebrospinal fluid (CSF) as the biomarker source. CSF has the advantage of being closer to the brain than serum or plasma with a relative enrichment of CNS‐specific proteins that ar...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.dadm.2016.05.005 |
| _version_ | 1811222777979469824 |
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| author | Ulf Andreasson Kaj Blennow Henrik Zetterberg |
| author_facet | Ulf Andreasson Kaj Blennow Henrik Zetterberg |
| author_sort | Ulf Andreasson |
| collection | DOAJ |
| description | Abstract Most research on fluid biomarkers for central nervous system (CNS) disorders has so far been performed using cerebrospinal fluid (CSF) as the biomarker source. CSF has the advantage of being closer to the brain than serum or plasma with a relative enrichment of CNS‐specific proteins that are present at very low concentrations in the blood and thus difficult to reliably quantify using standard immunochemical technologies. Recent technical breakthroughs in the field of ultrasensitive assays have started to change this. Here, we review the most established ultrasensitive quantitative technologies that are currently available to general biomarker laboratories and discuss their use in research on biomarkers for CNS disorders. |
| first_indexed | 2024-04-12T08:21:08Z |
| format | Article |
| id | doaj.art-82f1bf408033484c9b242a20368fe091 |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-04-12T08:21:08Z |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-82f1bf408033484c9b242a20368fe0912022-12-22T03:40:35ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292016-01-01319810210.1016/j.dadm.2016.05.005Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disordersUlf Andreasson0Kaj Blennow1Henrik Zetterberg2Department of Psychiatry and NeurochemistryInstitute of Neuroscience and Physiology, Sahlgrenska Academy at the University of GothenburgGothenburgSwedenDepartment of Psychiatry and NeurochemistryInstitute of Neuroscience and Physiology, Sahlgrenska Academy at the University of GothenburgGothenburgSwedenDepartment of Psychiatry and NeurochemistryInstitute of Neuroscience and Physiology, Sahlgrenska Academy at the University of GothenburgGothenburgSwedenAbstract Most research on fluid biomarkers for central nervous system (CNS) disorders has so far been performed using cerebrospinal fluid (CSF) as the biomarker source. CSF has the advantage of being closer to the brain than serum or plasma with a relative enrichment of CNS‐specific proteins that are present at very low concentrations in the blood and thus difficult to reliably quantify using standard immunochemical technologies. Recent technical breakthroughs in the field of ultrasensitive assays have started to change this. Here, we review the most established ultrasensitive quantitative technologies that are currently available to general biomarker laboratories and discuss their use in research on biomarkers for CNS disorders.https://doi.org/10.1016/j.dadm.2016.05.005BloodSerumPlasmaBiomarkersUltrasensitiveCentral nervous system |
| spellingShingle | Ulf Andreasson Kaj Blennow Henrik Zetterberg Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Blood Serum Plasma Biomarkers Ultrasensitive Central nervous system |
| title | Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders |
| title_full | Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders |
| title_fullStr | Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders |
| title_full_unstemmed | Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders |
| title_short | Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders |
| title_sort | update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders |
| topic | Blood Serum Plasma Biomarkers Ultrasensitive Central nervous system |
| url | https://doi.org/10.1016/j.dadm.2016.05.005 |
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