Analysis of Vaccinal Process Peculiarities in Persons Immunized with Smallpox Live Vaccine in Case of Primary Vaccination and Revaccination
Immunization against smallpox may be attended by serious complications. The premises for the differences in postvaccinal reaction intensity are underexplored. In this paper presented is the review of peculiarities of postvaccinal manifestations in members of the Russian population primarily immunize...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2015-03-01
|
| Series: | Проблемы особо опасных инфекций |
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/211 |
| _version_ | 1797220878690287616 |
|---|---|
| author | O. S. Ermilova Z. I. Gin’Ko V. A. Belyavskaya V. I. Kuzubov Ar. A. Sergeev D. O. Gorbatovskaya M. Sh. Azaev A. P. Agafonov M. I. Voevoda A. N. Sergeev |
| author_facet | O. S. Ermilova Z. I. Gin’Ko V. A. Belyavskaya V. I. Kuzubov Ar. A. Sergeev D. O. Gorbatovskaya M. Sh. Azaev A. P. Agafonov M. I. Voevoda A. N. Sergeev |
| author_sort | O. S. Ermilova |
| collection | DOAJ |
| description | Immunization against smallpox may be attended by serious complications. The premises for the differences in postvaccinal reaction intensity are underexplored. In this paper presented is the review of peculiarities of postvaccinal manifestations in members of the Russian population primarily immunized against smallpox as compared to the revaccinated ones. Examined has been the cohort of 217 people, of whom 82 are vaccinated initially, and 135 - repeatedly within the period from 2000 to 2013. Average age of the vaccinated is 40.0 years (ranged 20 to 40). Studied has been severity of vaccine-challenged condition and cutaneous inflammatory vaccinal elements. In case of initial vaccination medium severity has been observed 2.1 times oftener than low one. In case of revaccination - low level of severity has been registered 17.7 times more frequently than the medium one. Hyperemia zone is 2.2 times greater as regards primary vaccination compared to revaccination, zone of induration - 1.9 times. The diameter of the sore is 1.3 and its shedding time is 1.4 times greater and longer, respectively. Thus, initial vaccination follows more severe course and is attended by expressed response in comparison to booster one. |
| first_indexed | 2024-03-08T13:43:30Z |
| format | Article |
| id | doaj.art-82f351a3f84d4aa2a7a538b57881334c |
| institution | Directory Open Access Journal |
| issn | 0370-1069 2658-719X |
| language | Russian |
| last_indexed | 2024-04-24T12:56:32Z |
| publishDate | 2015-03-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| series | Проблемы особо опасных инфекций |
| spelling | doaj.art-82f351a3f84d4aa2a7a538b57881334c2024-04-05T16:47:10ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2015-03-0101757810.21055/0370-1069-2015-1-75-78211Analysis of Vaccinal Process Peculiarities in Persons Immunized with Smallpox Live Vaccine in Case of Primary Vaccination and RevaccinationO. S. Ermilova0Z. I. Gin’Ko1V. A. Belyavskaya2V. I. Kuzubov3Ar. A. Sergeev4D. O. Gorbatovskaya5M. Sh. Azaev6A. P. Agafonov7M. I. Voevoda8A. N. Sergeev9State Research Centre of Virology and Biotechnology “Vector”Health Facility No 163 of Federal Medical-Biological Agency of RussiaState Research Centre of Virology and Biotechnology “Vector”Health Facility No 163 of Federal Medical-Biological Agency of RussiaState Research Centre of Virology and Biotechnology “Vector”State Research Centre of Virology and Biotechnology “Vector”State Research Centre of Virology and Biotechnology “Vector”State Research Centre of Virology and Biotechnology “Vector”Research Institute of Therapy, RAMS Siberian BrunchState Research Centre of Virology and Biotechnology “Vector”Immunization against smallpox may be attended by serious complications. The premises for the differences in postvaccinal reaction intensity are underexplored. In this paper presented is the review of peculiarities of postvaccinal manifestations in members of the Russian population primarily immunized against smallpox as compared to the revaccinated ones. Examined has been the cohort of 217 people, of whom 82 are vaccinated initially, and 135 - repeatedly within the period from 2000 to 2013. Average age of the vaccinated is 40.0 years (ranged 20 to 40). Studied has been severity of vaccine-challenged condition and cutaneous inflammatory vaccinal elements. In case of initial vaccination medium severity has been observed 2.1 times oftener than low one. In case of revaccination - low level of severity has been registered 17.7 times more frequently than the medium one. Hyperemia zone is 2.2 times greater as regards primary vaccination compared to revaccination, zone of induration - 1.9 times. The diameter of the sore is 1.3 and its shedding time is 1.4 times greater and longer, respectively. Thus, initial vaccination follows more severe course and is attended by expressed response in comparison to booster one.https://journal.microbe.ru/jour/article/view/211вакцинациянатуральная оспаклинические признакинакожная вакцинациявакцинальные реакцииvaccinationsmallpoxclinical signssupracutaneous vaccinationvaccinal reactions |
| spellingShingle | O. S. Ermilova Z. I. Gin’Ko V. A. Belyavskaya V. I. Kuzubov Ar. A. Sergeev D. O. Gorbatovskaya M. Sh. Azaev A. P. Agafonov M. I. Voevoda A. N. Sergeev Analysis of Vaccinal Process Peculiarities in Persons Immunized with Smallpox Live Vaccine in Case of Primary Vaccination and Revaccination Проблемы особо опасных инфекций вакцинация натуральная оспа клинические признаки накожная вакцинация вакцинальные реакции vaccination smallpox clinical signs supracutaneous vaccination vaccinal reactions |
| title | Analysis of Vaccinal Process Peculiarities in Persons Immunized with Smallpox Live Vaccine in Case of Primary Vaccination and Revaccination |
| title_full | Analysis of Vaccinal Process Peculiarities in Persons Immunized with Smallpox Live Vaccine in Case of Primary Vaccination and Revaccination |
| title_fullStr | Analysis of Vaccinal Process Peculiarities in Persons Immunized with Smallpox Live Vaccine in Case of Primary Vaccination and Revaccination |
| title_full_unstemmed | Analysis of Vaccinal Process Peculiarities in Persons Immunized with Smallpox Live Vaccine in Case of Primary Vaccination and Revaccination |
| title_short | Analysis of Vaccinal Process Peculiarities in Persons Immunized with Smallpox Live Vaccine in Case of Primary Vaccination and Revaccination |
| title_sort | analysis of vaccinal process peculiarities in persons immunized with smallpox live vaccine in case of primary vaccination and revaccination |
| topic | вакцинация натуральная оспа клинические признаки накожная вакцинация вакцинальные реакции vaccination smallpox clinical signs supracutaneous vaccination vaccinal reactions |
| url | https://journal.microbe.ru/jour/article/view/211 |
| work_keys_str_mv | AT osermilova analysisofvaccinalprocesspeculiaritiesinpersonsimmunizedwithsmallpoxlivevaccineincaseofprimaryvaccinationandrevaccination AT ziginko analysisofvaccinalprocesspeculiaritiesinpersonsimmunizedwithsmallpoxlivevaccineincaseofprimaryvaccinationandrevaccination AT vabelyavskaya analysisofvaccinalprocesspeculiaritiesinpersonsimmunizedwithsmallpoxlivevaccineincaseofprimaryvaccinationandrevaccination AT vikuzubov analysisofvaccinalprocesspeculiaritiesinpersonsimmunizedwithsmallpoxlivevaccineincaseofprimaryvaccinationandrevaccination AT arasergeev analysisofvaccinalprocesspeculiaritiesinpersonsimmunizedwithsmallpoxlivevaccineincaseofprimaryvaccinationandrevaccination AT dogorbatovskaya analysisofvaccinalprocesspeculiaritiesinpersonsimmunizedwithsmallpoxlivevaccineincaseofprimaryvaccinationandrevaccination AT mshazaev analysisofvaccinalprocesspeculiaritiesinpersonsimmunizedwithsmallpoxlivevaccineincaseofprimaryvaccinationandrevaccination AT apagafonov analysisofvaccinalprocesspeculiaritiesinpersonsimmunizedwithsmallpoxlivevaccineincaseofprimaryvaccinationandrevaccination AT mivoevoda analysisofvaccinalprocesspeculiaritiesinpersonsimmunizedwithsmallpoxlivevaccineincaseofprimaryvaccinationandrevaccination AT ansergeev analysisofvaccinalprocesspeculiaritiesinpersonsimmunizedwithsmallpoxlivevaccineincaseofprimaryvaccinationandrevaccination |