Phospholipases A and Lysophospholipases in protozoan parasites
Phospholipases (PLs) and Lysophospholipases (LysoPLs) are a diverse group of esterases responsible for phospholipid or lysophospholipid hydrolysis. They are involved in several biological processes, including lipid catabolism, modulation of the immune response and membrane maintenance. PLs are class...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2023-10-01
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| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/2023a-hervé-microbial-cell/ |
| _version_ | 1797679831713841152 |
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| author | Perrine Hervé Sarah Monic Frédéric Bringaud Loïc Rivière |
| author_facet | Perrine Hervé Sarah Monic Frédéric Bringaud Loïc Rivière |
| author_sort | Perrine Hervé |
| collection | DOAJ |
| description | Phospholipases (PLs) and Lysophospholipases (LysoPLs) are a diverse group of esterases responsible for phospholipid or lysophospholipid hydrolysis. They are involved in several biological processes, including lipid catabolism, modulation of the immune response and membrane maintenance. PLs are classified depending on their site of hydrolysis as PLA1, PLA2, PLC and PLD. In many pathogenic microorganisms, from bacteria to fungi, PLAs and LysoPLs have been described as critical virulence and/or pathogenicity factors. In protozoan parasites, a group containing major human and animal pathogens, growing literature show that PLAs and LysoPLs are also involved in the host infection. Their ubiquitous presence and role in host-pathogen interactions make them particularly interesting to study. In this review, we summarize the literature on PLAs and LysoPLs in several protozoan parasites of medical relevance, and discuss the growing interest for them as potential drug and vaccine targets. |
| first_indexed | 2024-03-11T23:20:37Z |
| format | Article |
| id | doaj.art-82f3ee0e7edb4ce8923dc1e0848ff60f |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2024-03-11T23:20:37Z |
| publishDate | 2023-10-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-82f3ee0e7edb4ce8923dc1e0848ff60f2023-09-20T15:42:29ZengShared Science Publishers OGMicrobial Cell2311-26382023-10-01101020421610.15698/mic2023.10.805Phospholipases A and Lysophospholipases in protozoan parasitesPerrine Hervé0Sarah Monic1Frédéric Bringaud2Loïc Rivière3Université de Bordeaux, Microbiologie Fondamentale et Pathogénicité, CNRS UMR 5234, Bordeaux, France.Université de Bordeaux, Microbiologie Fondamentale et Pathogénicité, CNRS UMR 5234, Bordeaux, France.Université de Bordeaux, Microbiologie Fondamentale et Pathogénicité, CNRS UMR 5234, Bordeaux, France.Université de Bordeaux, Microbiologie Fondamentale et Pathogénicité, CNRS UMR 5234, Bordeaux, France.Phospholipases (PLs) and Lysophospholipases (LysoPLs) are a diverse group of esterases responsible for phospholipid or lysophospholipid hydrolysis. They are involved in several biological processes, including lipid catabolism, modulation of the immune response and membrane maintenance. PLs are classified depending on their site of hydrolysis as PLA1, PLA2, PLC and PLD. In many pathogenic microorganisms, from bacteria to fungi, PLAs and LysoPLs have been described as critical virulence and/or pathogenicity factors. In protozoan parasites, a group containing major human and animal pathogens, growing literature show that PLAs and LysoPLs are also involved in the host infection. Their ubiquitous presence and role in host-pathogen interactions make them particularly interesting to study. In this review, we summarize the literature on PLAs and LysoPLs in several protozoan parasites of medical relevance, and discuss the growing interest for them as potential drug and vaccine targets.http://microbialcell.com/researcharticles/2023a-hervé-microbial-cell/phospholipaseslysophospholipasesprotozoanhost-pathogen interactionsvirulence factorsmetabolism |
| spellingShingle | Perrine Hervé Sarah Monic Frédéric Bringaud Loïc Rivière Phospholipases A and Lysophospholipases in protozoan parasites Microbial Cell phospholipases lysophospholipases protozoan host-pathogen interactions virulence factors metabolism |
| title | Phospholipases A and Lysophospholipases in protozoan parasites |
| title_full | Phospholipases A and Lysophospholipases in protozoan parasites |
| title_fullStr | Phospholipases A and Lysophospholipases in protozoan parasites |
| title_full_unstemmed | Phospholipases A and Lysophospholipases in protozoan parasites |
| title_short | Phospholipases A and Lysophospholipases in protozoan parasites |
| title_sort | phospholipases a and lysophospholipases in protozoan parasites |
| topic | phospholipases lysophospholipases protozoan host-pathogen interactions virulence factors metabolism |
| url | http://microbialcell.com/researcharticles/2023a-hervé-microbial-cell/ |
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