Oncological Outcomes of Open Radical Retropubic Prostatectomy in Ireland: A Single Surgeon's 5-Year Experience
Abstract Objectives There is a little published data on the outcomes of radical prostatectomy in the Irish context. We aimed to determine the 5-year oncological results of open radical retropubic prostatectomy (RRP) performed by a single surgeon following appointment. Metho...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical Publishers, Inc.
2018-10-01
|
| Series: | The Surgery Journal |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1675827 |
| _version_ | 1818949546113236992 |
|---|---|
| author | Stefanie M. Croghan Deep Mudit Matanhelia Ann T. Foran David J. Galvin |
| author_facet | Stefanie M. Croghan Deep Mudit Matanhelia Ann T. Foran David J. Galvin |
| author_sort | Stefanie M. Croghan |
| collection | DOAJ |
| description | Abstract
Objectives There is a little published data on the outcomes of radical prostatectomy in the Irish context. We aimed to determine the 5-year oncological results of open radical retropubic prostatectomy (RRP) performed by a single surgeon following appointment.
Methods A retrospective review of RRPs performed between 2011 and 2016 was conducted. Patient demographics, preoperative parameters (clinical stage on digital rectal exam, prostate-specific antigen (PSA) levels, biopsy Gleason's score and MRI [magnetic resonance imaging] findings), pathological variables (T-stage, Gleason's score, nodal status, and surgical margin status), and treatment decisions (lymphadenectomy or adjuvant radiotherapy) were recorded. Oncological outcome at last follow-up was ascertained.
Results 265 patients underwent RRP between 2011 and 2016. Median age was 62 years (range: 41–74). Mean follow-up was 32.24 months (range: 8–72) months. Pathological disease stage was T2 in 170/265 (64.15%), T3a in 65/265 (24.53%), and T3b in 30/265 (11.32%). Final Gleason's score was upgraded from diagnostic biopsy in 16.35% (43/263) and downgraded in 27% (71/263). Pelvic lymph node dissection was performed in 44.25% (118/265) patients. A positive surgical margin (PSM) was seen in 26/170 (15.2%) patients with T2 disease and in 45/95 (47.37%) patients with T3 disease. Of the 265 patients, 238 (89.81%) were disease-free at last follow-up, of whom 24/238 (10.08%) had received adjuvant and 17/238 (7.14%) received salvage radiotherapy. Adjuvant/salvage treatment was ongoing in 19/265 (7.17%) of patients.
Conclusion Good oncological outcomes of RRP in the Irish context are seen in this 5-year review, with the vast majority of patients experiencing biochemical-free survival at most recent follow-up. |
| first_indexed | 2024-12-20T09:04:24Z |
| format | Article |
| id | doaj.art-82f50c1fc5ec4830ada327698b4d29d4 |
| institution | Directory Open Access Journal |
| issn | 2378-5128 2378-5136 |
| language | English |
| last_indexed | 2024-12-20T09:04:24Z |
| publishDate | 2018-10-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | The Surgery Journal |
| spelling | doaj.art-82f50c1fc5ec4830ada327698b4d29d42022-12-21T19:45:45ZengThieme Medical Publishers, Inc.The Surgery Journal2378-51282378-51362018-10-010404e226e23410.1055/s-0038-1675827Oncological Outcomes of Open Radical Retropubic Prostatectomy in Ireland: A Single Surgeon's 5-Year ExperienceStefanie M. Croghan0Deep Mudit Matanhelia1Ann T. Foran2David J. Galvin3Department of Urology, The Mater Misericordiae University Hospital, Eccles Street, Dublin, IrelandDepartment of Urology, St. Vincent's University Hospital, Elm Park, Dublin, IrelandDepartment of Urology, The Mater Misericordiae University Hospital, Eccles Street, Dublin, IrelandDepartment of Urology, The Mater Misericordiae University Hospital, Eccles Street, Dublin, IrelandAbstract Objectives There is a little published data on the outcomes of radical prostatectomy in the Irish context. We aimed to determine the 5-year oncological results of open radical retropubic prostatectomy (RRP) performed by a single surgeon following appointment. Methods A retrospective review of RRPs performed between 2011 and 2016 was conducted. Patient demographics, preoperative parameters (clinical stage on digital rectal exam, prostate-specific antigen (PSA) levels, biopsy Gleason's score and MRI [magnetic resonance imaging] findings), pathological variables (T-stage, Gleason's score, nodal status, and surgical margin status), and treatment decisions (lymphadenectomy or adjuvant radiotherapy) were recorded. Oncological outcome at last follow-up was ascertained. Results 265 patients underwent RRP between 2011 and 2016. Median age was 62 years (range: 41–74). Mean follow-up was 32.24 months (range: 8–72) months. Pathological disease stage was T2 in 170/265 (64.15%), T3a in 65/265 (24.53%), and T3b in 30/265 (11.32%). Final Gleason's score was upgraded from diagnostic biopsy in 16.35% (43/263) and downgraded in 27% (71/263). Pelvic lymph node dissection was performed in 44.25% (118/265) patients. A positive surgical margin (PSM) was seen in 26/170 (15.2%) patients with T2 disease and in 45/95 (47.37%) patients with T3 disease. Of the 265 patients, 238 (89.81%) were disease-free at last follow-up, of whom 24/238 (10.08%) had received adjuvant and 17/238 (7.14%) received salvage radiotherapy. Adjuvant/salvage treatment was ongoing in 19/265 (7.17%) of patients. Conclusion Good oncological outcomes of RRP in the Irish context are seen in this 5-year review, with the vast majority of patients experiencing biochemical-free survival at most recent follow-up.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1675827radical retropubic prostatectomyrrpopen prostatectomyprostate canceroncological outcomes |
| spellingShingle | Stefanie M. Croghan Deep Mudit Matanhelia Ann T. Foran David J. Galvin Oncological Outcomes of Open Radical Retropubic Prostatectomy in Ireland: A Single Surgeon's 5-Year Experience The Surgery Journal radical retropubic prostatectomy rrp open prostatectomy prostate cancer oncological outcomes |
| title | Oncological Outcomes of Open Radical Retropubic Prostatectomy in Ireland: A Single Surgeon's 5-Year Experience |
| title_full | Oncological Outcomes of Open Radical Retropubic Prostatectomy in Ireland: A Single Surgeon's 5-Year Experience |
| title_fullStr | Oncological Outcomes of Open Radical Retropubic Prostatectomy in Ireland: A Single Surgeon's 5-Year Experience |
| title_full_unstemmed | Oncological Outcomes of Open Radical Retropubic Prostatectomy in Ireland: A Single Surgeon's 5-Year Experience |
| title_short | Oncological Outcomes of Open Radical Retropubic Prostatectomy in Ireland: A Single Surgeon's 5-Year Experience |
| title_sort | oncological outcomes of open radical retropubic prostatectomy in ireland a single surgeon s 5 year experience |
| topic | radical retropubic prostatectomy rrp open prostatectomy prostate cancer oncological outcomes |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1675827 |
| work_keys_str_mv | AT stefaniemcroghan oncologicaloutcomesofopenradicalretropubicprostatectomyinirelandasinglesurgeons5yearexperience AT deepmuditmatanhelia oncologicaloutcomesofopenradicalretropubicprostatectomyinirelandasinglesurgeons5yearexperience AT anntforan oncologicaloutcomesofopenradicalretropubicprostatectomyinirelandasinglesurgeons5yearexperience AT davidjgalvin oncologicaloutcomesofopenradicalretropubicprostatectomyinirelandasinglesurgeons5yearexperience |