A Facile Surface Modification Scheme for Medical-Grade Titanium and Polypropylene Using a Novel Mussel-Inspired Biomimetic Polymer with Cationic Quaternary Ammonium Functionalities for Antibacterial Application
Medical device-associated infection remains a critical problem in the healthcare setting. Different clinical- or device-related methods have been attempted to reduce the infection rate. Among these approaches, creating a surface with bactericidal cationic functionality has been proposed. To do so, a...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/16/4/503 |
| _version_ | 1797297145498304512 |
|---|---|
| author | Chi-Hui Cheng Xiang-Zhen Zeng Wen-Yuan Chiu Jui-Che Lin |
| author_facet | Chi-Hui Cheng Xiang-Zhen Zeng Wen-Yuan Chiu Jui-Che Lin |
| author_sort | Chi-Hui Cheng |
| collection | DOAJ |
| description | Medical device-associated infection remains a critical problem in the healthcare setting. Different clinical- or device-related methods have been attempted to reduce the infection rate. Among these approaches, creating a surface with bactericidal cationic functionality has been proposed. To do so, a sophisticated multi-step chemical procedure would be needed. Instead, a simple immersion approach was utilized in this investigation to render the titanium and polypropylene surface with the quaternary ammonium functionality by using a mussel-inspired novel lab-synthesized biomimetic catechol-terminated polymer, PQA-C8. The chemical oxidants, CuSO<sub>4</sub>/H<sub>2</sub>O<sub>2</sub>, as well as dopamine, were added into the novel PQA-C8 polymer immersion solution for one-step surface modification. Additionally, a two-step immersion scheme, in which the polypropylene substrate was first immersed in the dopamine solution and then in the PQA-C8 solution, was also attempted. Surface analysis results indicated the surface characteristics of the modified substrates were affected by the immersion solution formulation as well as the procedure utilized. The antibacterial assay has shown the titanium substrates modified by the one-step dopamine + PQA-C8 mixtures with the oxidants added and the polypropylene modified by the two-step scheme exhibited bacterial reduction percentages greater than 90% against both Gram-positive <i>S. aureus</i> and Gram-negative <i>E. coli</i> and these antibacterial substrates were non-cytotoxic. |
| first_indexed | 2024-03-07T22:17:05Z |
| format | Article |
| id | doaj.art-82f5d4f6275143ce95319602ff3ca041 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-07T22:17:05Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-82f5d4f6275143ce95319602ff3ca0412024-02-23T15:32:17ZengMDPI AGPolymers2073-43602024-02-0116450310.3390/polym16040503A Facile Surface Modification Scheme for Medical-Grade Titanium and Polypropylene Using a Novel Mussel-Inspired Biomimetic Polymer with Cationic Quaternary Ammonium Functionalities for Antibacterial ApplicationChi-Hui Cheng0Xiang-Zhen Zeng1Wen-Yuan Chiu2Jui-Che Lin3Department of Pediatrics, College of Medicine, Chang Gung University, Chang Gung Memorial Hospital, Taoyuan 33305, TaiwanDepartment of Chemical Engineering, National Cheng Kung University, Tainan 70101, TaiwanDepartment of Chemical Engineering, National Cheng Kung University, Tainan 70101, TaiwanDepartment of Chemical Engineering, National Cheng Kung University, Tainan 70101, TaiwanMedical device-associated infection remains a critical problem in the healthcare setting. Different clinical- or device-related methods have been attempted to reduce the infection rate. Among these approaches, creating a surface with bactericidal cationic functionality has been proposed. To do so, a sophisticated multi-step chemical procedure would be needed. Instead, a simple immersion approach was utilized in this investigation to render the titanium and polypropylene surface with the quaternary ammonium functionality by using a mussel-inspired novel lab-synthesized biomimetic catechol-terminated polymer, PQA-C8. The chemical oxidants, CuSO<sub>4</sub>/H<sub>2</sub>O<sub>2</sub>, as well as dopamine, were added into the novel PQA-C8 polymer immersion solution for one-step surface modification. Additionally, a two-step immersion scheme, in which the polypropylene substrate was first immersed in the dopamine solution and then in the PQA-C8 solution, was also attempted. Surface analysis results indicated the surface characteristics of the modified substrates were affected by the immersion solution formulation as well as the procedure utilized. The antibacterial assay has shown the titanium substrates modified by the one-step dopamine + PQA-C8 mixtures with the oxidants added and the polypropylene modified by the two-step scheme exhibited bacterial reduction percentages greater than 90% against both Gram-positive <i>S. aureus</i> and Gram-negative <i>E. coli</i> and these antibacterial substrates were non-cytotoxic.https://www.mdpi.com/2073-4360/16/4/503quaternary ammoniumantibacterialdopaminemussel-inspiredsurface modification |
| spellingShingle | Chi-Hui Cheng Xiang-Zhen Zeng Wen-Yuan Chiu Jui-Che Lin A Facile Surface Modification Scheme for Medical-Grade Titanium and Polypropylene Using a Novel Mussel-Inspired Biomimetic Polymer with Cationic Quaternary Ammonium Functionalities for Antibacterial Application Polymers quaternary ammonium antibacterial dopamine mussel-inspired surface modification |
| title | A Facile Surface Modification Scheme for Medical-Grade Titanium and Polypropylene Using a Novel Mussel-Inspired Biomimetic Polymer with Cationic Quaternary Ammonium Functionalities for Antibacterial Application |
| title_full | A Facile Surface Modification Scheme for Medical-Grade Titanium and Polypropylene Using a Novel Mussel-Inspired Biomimetic Polymer with Cationic Quaternary Ammonium Functionalities for Antibacterial Application |
| title_fullStr | A Facile Surface Modification Scheme for Medical-Grade Titanium and Polypropylene Using a Novel Mussel-Inspired Biomimetic Polymer with Cationic Quaternary Ammonium Functionalities for Antibacterial Application |
| title_full_unstemmed | A Facile Surface Modification Scheme for Medical-Grade Titanium and Polypropylene Using a Novel Mussel-Inspired Biomimetic Polymer with Cationic Quaternary Ammonium Functionalities for Antibacterial Application |
| title_short | A Facile Surface Modification Scheme for Medical-Grade Titanium and Polypropylene Using a Novel Mussel-Inspired Biomimetic Polymer with Cationic Quaternary Ammonium Functionalities for Antibacterial Application |
| title_sort | facile surface modification scheme for medical grade titanium and polypropylene using a novel mussel inspired biomimetic polymer with cationic quaternary ammonium functionalities for antibacterial application |
| topic | quaternary ammonium antibacterial dopamine mussel-inspired surface modification |
| url | https://www.mdpi.com/2073-4360/16/4/503 |
| work_keys_str_mv | AT chihuicheng afacilesurfacemodificationschemeformedicalgradetitaniumandpolypropyleneusinganovelmusselinspiredbiomimeticpolymerwithcationicquaternaryammoniumfunctionalitiesforantibacterialapplication AT xiangzhenzeng afacilesurfacemodificationschemeformedicalgradetitaniumandpolypropyleneusinganovelmusselinspiredbiomimeticpolymerwithcationicquaternaryammoniumfunctionalitiesforantibacterialapplication AT wenyuanchiu afacilesurfacemodificationschemeformedicalgradetitaniumandpolypropyleneusinganovelmusselinspiredbiomimeticpolymerwithcationicquaternaryammoniumfunctionalitiesforantibacterialapplication AT juichelin afacilesurfacemodificationschemeformedicalgradetitaniumandpolypropyleneusinganovelmusselinspiredbiomimeticpolymerwithcationicquaternaryammoniumfunctionalitiesforantibacterialapplication AT chihuicheng facilesurfacemodificationschemeformedicalgradetitaniumandpolypropyleneusinganovelmusselinspiredbiomimeticpolymerwithcationicquaternaryammoniumfunctionalitiesforantibacterialapplication AT xiangzhenzeng facilesurfacemodificationschemeformedicalgradetitaniumandpolypropyleneusinganovelmusselinspiredbiomimeticpolymerwithcationicquaternaryammoniumfunctionalitiesforantibacterialapplication AT wenyuanchiu facilesurfacemodificationschemeformedicalgradetitaniumandpolypropyleneusinganovelmusselinspiredbiomimeticpolymerwithcationicquaternaryammoniumfunctionalitiesforantibacterialapplication AT juichelin facilesurfacemodificationschemeformedicalgradetitaniumandpolypropyleneusinganovelmusselinspiredbiomimeticpolymerwithcationicquaternaryammoniumfunctionalitiesforantibacterialapplication |