Treatment of infectious diseases by <italic>in vivo</italic> gene editing
<p indent="0mm">Gene editing is the specific modification of genome sequences at desired sites using technologies derived from zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR)...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Science Press
2023-08-01
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| Series: | National Science Open |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.1360/nso/20220061 |
| _version_ | 1797663880614248448 |
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| author | Wu Yuxuan Zhang Haokun |
| author_facet | Wu Yuxuan Zhang Haokun |
| author_sort | Wu Yuxuan |
| collection | DOAJ |
| description | <p indent="0mm">Gene editing is the specific modification of genome sequences at desired sites using technologies derived from zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) nuclease systems. It is a promising tool for the development of new treatment strategies for infectious diseases. Due to its higher editing efficiency and lower off-target effect, gene editing therapy mainly uses CRISPR Cas-derived tools to resist viral and non-viral infections. Here, we reviewed the recent research progress of gene editing in antiviral therapy (human immunodeficiency virus, hepatitis B virus, severe acute respiratory syndrome coronavirus 2, and human papillomavirus) and inhibition of infectious diseases that involve bacteria, fungi and parasites.</p> |
| first_indexed | 2024-03-11T19:21:11Z |
| format | Article |
| id | doaj.art-82f6bb5599774d5a8e0453e99da137dc |
| institution | Directory Open Access Journal |
| issn | 2097-1168 |
| language | English |
| last_indexed | 2024-03-11T19:21:11Z |
| publishDate | 2023-08-01 |
| publisher | Science Press |
| record_format | Article |
| series | National Science Open |
| spelling | doaj.art-82f6bb5599774d5a8e0453e99da137dc2023-10-07T08:11:46ZengScience PressNational Science Open2097-11682023-08-01210.1360/nso/20220061eb33e642Treatment of infectious diseases by <italic>in vivo</italic> gene editingWu Yuxuan0Zhang Haokun1["Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai 200241, China;","Yoltech Therapeutics, Shanghai 200241, China"]["Yoltech Therapeutics, Shanghai 200241, China"]<p indent="0mm">Gene editing is the specific modification of genome sequences at desired sites using technologies derived from zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) nuclease systems. It is a promising tool for the development of new treatment strategies for infectious diseases. Due to its higher editing efficiency and lower off-target effect, gene editing therapy mainly uses CRISPR Cas-derived tools to resist viral and non-viral infections. Here, we reviewed the recent research progress of gene editing in antiviral therapy (human immunodeficiency virus, hepatitis B virus, severe acute respiratory syndrome coronavirus 2, and human papillomavirus) and inhibition of infectious diseases that involve bacteria, fungi and parasites.</p>https://www.sciengine.com/doi/10.1360/nso/20220061gene editing<italic>in vivo</italic> therapyCRISPR-Casinfectious diseasesviral infection |
| spellingShingle | Wu Yuxuan Zhang Haokun Treatment of infectious diseases by <italic>in vivo</italic> gene editing National Science Open gene editing <italic>in vivo</italic> therapy CRISPR-Cas infectious diseases viral infection |
| title | Treatment of infectious diseases by <italic>in vivo</italic> gene editing |
| title_full | Treatment of infectious diseases by <italic>in vivo</italic> gene editing |
| title_fullStr | Treatment of infectious diseases by <italic>in vivo</italic> gene editing |
| title_full_unstemmed | Treatment of infectious diseases by <italic>in vivo</italic> gene editing |
| title_short | Treatment of infectious diseases by <italic>in vivo</italic> gene editing |
| title_sort | treatment of infectious diseases by italic in vivo italic gene editing |
| topic | gene editing <italic>in vivo</italic> therapy CRISPR-Cas infectious diseases viral infection |
| url | https://www.sciengine.com/doi/10.1360/nso/20220061 |
| work_keys_str_mv | AT wuyuxuan treatmentofinfectiousdiseasesbyitalicinvivoitalicgeneediting AT zhanghaokun treatmentofinfectiousdiseasesbyitalicinvivoitalicgeneediting |