The Development of New Methods to Stimulate the Production of Antimicrobial Peptides in the Larvae of the Black Soldier Fly <i>Hermetia illucens</i>
(1) The global population is projected to reach a staggering 9.8 billion people by the year 2050, leading to major concerns about food security. The necessity to increase livestock production is inevitable. The black soldier fly (BSF) is known for its ability to consume a wide range of organic waste...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/21/15765 |
| _version_ | 1797631796902363136 |
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| author | Atsuyoshi Nakagawa Takuma Sakamoto Michael R. Kanost Hiroko Tabunoki |
| author_facet | Atsuyoshi Nakagawa Takuma Sakamoto Michael R. Kanost Hiroko Tabunoki |
| author_sort | Atsuyoshi Nakagawa |
| collection | DOAJ |
| description | (1) The global population is projected to reach a staggering 9.8 billion people by the year 2050, leading to major concerns about food security. The necessity to increase livestock production is inevitable. The black soldier fly (BSF) is known for its ability to consume a wide range of organic waste, and BSF larvae have already been used as a partial substitute for fishmeal. In contrast, the use of antibiotics in livestock feed for growth promotion and prophylaxis poses a severe threat to global health owing to antimicrobial resistance. Insect antimicrobial peptides (AMPs) have shown the potential to rapidly disrupt target bacterial membranes, making bacterial resistance to AMPs a less likely concern. (2) In this study, we explored various methods for stimulating AMP synthesis in BSF larvae and found that thermal injury effectively induced the production of various AMP types. Additionally, we investigated the activation of innate immune response pathways that lead to AMP production following thermal injury. (3) Interestingly, thermal injury treatment, although not involving bacteria, exhibited a similar response to that observed following Gram-positive bacterial infection in eliciting the expression of AMP genes. (4) Our findings offer support for the industrial use of BSF to enhance livestock production and promote environmental health. |
| first_indexed | 2024-03-11T11:28:48Z |
| format | Article |
| id | doaj.art-82f83227f78e4649b5fd7a437d437567 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T11:28:48Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-82f83227f78e4649b5fd7a437d4375672023-11-10T15:05:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124211576510.3390/ijms242115765The Development of New Methods to Stimulate the Production of Antimicrobial Peptides in the Larvae of the Black Soldier Fly <i>Hermetia illucens</i>Atsuyoshi Nakagawa0Takuma Sakamoto1Michael R. Kanost2Hiroko Tabunoki3Future Tech Laboratory, Corporate Research & Development, UBE Corporation, 8-1 Goi-Minamikaigan, Chiba 290-0045, JapanDepartment of Science of Biological Production, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-Cho, Tokyo 183-8509, JapanDepartment of Biochemistry and Molecular Biophysics, Kansas State University, 141 Chalmers Hall, Manhattan, KS 66506-3702, USACooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan(1) The global population is projected to reach a staggering 9.8 billion people by the year 2050, leading to major concerns about food security. The necessity to increase livestock production is inevitable. The black soldier fly (BSF) is known for its ability to consume a wide range of organic waste, and BSF larvae have already been used as a partial substitute for fishmeal. In contrast, the use of antibiotics in livestock feed for growth promotion and prophylaxis poses a severe threat to global health owing to antimicrobial resistance. Insect antimicrobial peptides (AMPs) have shown the potential to rapidly disrupt target bacterial membranes, making bacterial resistance to AMPs a less likely concern. (2) In this study, we explored various methods for stimulating AMP synthesis in BSF larvae and found that thermal injury effectively induced the production of various AMP types. Additionally, we investigated the activation of innate immune response pathways that lead to AMP production following thermal injury. (3) Interestingly, thermal injury treatment, although not involving bacteria, exhibited a similar response to that observed following Gram-positive bacterial infection in eliciting the expression of AMP genes. (4) Our findings offer support for the industrial use of BSF to enhance livestock production and promote environmental health.https://www.mdpi.com/1422-0067/24/21/15765black soldier flyantimicrobial peptides (AMPs)thermal injuryGram-positive bacteria |
| spellingShingle | Atsuyoshi Nakagawa Takuma Sakamoto Michael R. Kanost Hiroko Tabunoki The Development of New Methods to Stimulate the Production of Antimicrobial Peptides in the Larvae of the Black Soldier Fly <i>Hermetia illucens</i> International Journal of Molecular Sciences black soldier fly antimicrobial peptides (AMPs) thermal injury Gram-positive bacteria |
| title | The Development of New Methods to Stimulate the Production of Antimicrobial Peptides in the Larvae of the Black Soldier Fly <i>Hermetia illucens</i> |
| title_full | The Development of New Methods to Stimulate the Production of Antimicrobial Peptides in the Larvae of the Black Soldier Fly <i>Hermetia illucens</i> |
| title_fullStr | The Development of New Methods to Stimulate the Production of Antimicrobial Peptides in the Larvae of the Black Soldier Fly <i>Hermetia illucens</i> |
| title_full_unstemmed | The Development of New Methods to Stimulate the Production of Antimicrobial Peptides in the Larvae of the Black Soldier Fly <i>Hermetia illucens</i> |
| title_short | The Development of New Methods to Stimulate the Production of Antimicrobial Peptides in the Larvae of the Black Soldier Fly <i>Hermetia illucens</i> |
| title_sort | development of new methods to stimulate the production of antimicrobial peptides in the larvae of the black soldier fly i hermetia illucens i |
| topic | black soldier fly antimicrobial peptides (AMPs) thermal injury Gram-positive bacteria |
| url | https://www.mdpi.com/1422-0067/24/21/15765 |
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