Hippocampal-evoked inhibition of cholinergic interneurons in the nucleus accumbens
Summary: Cholinergic interneurons (ChIs) in the nucleus accumbens (NAc) play a central role in motivated behaviors and associated disorders. However, while the activation of ChIs has been well studied in the dorsal striatum, little is known about how they are engaged in the NAc. Here, we find that t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124722008361 |
| _version_ | 1828775195274379264 |
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| author | Corey Baimel Emily Jang Samantha L. Scudder Kasra Manoocheri Adam G. Carter |
| author_facet | Corey Baimel Emily Jang Samantha L. Scudder Kasra Manoocheri Adam G. Carter |
| author_sort | Corey Baimel |
| collection | DOAJ |
| description | Summary: Cholinergic interneurons (ChIs) in the nucleus accumbens (NAc) play a central role in motivated behaviors and associated disorders. However, while the activation of ChIs has been well studied in the dorsal striatum, little is known about how they are engaged in the NAc. Here, we find that the ventral hippocampus (vHPC) and the paraventricular nucleus of the thalamus (PVT) are the main excitatory inputs to ChIs in the NAc medial shell. While the PVT activates ChIs, the vHPC evokes a pronounced pause in firing through prominent feedforward inhibition. In contrast to the dorsal striatum, this inhibition reflects strong connections onto ChIs from local parvalbumin interneurons. Our results reveal the mechanisms by which different long-range inputs engage ChIs, highlighting fundamental differences in local connectivity across the striatum. |
| first_indexed | 2024-12-11T15:34:45Z |
| format | Article |
| id | doaj.art-82f87dd534774a919f55a950b3729e12 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-11T15:34:45Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-82f87dd534774a919f55a950b3729e122022-12-22T00:59:58ZengElsevierCell Reports2211-12472022-07-01401111042Hippocampal-evoked inhibition of cholinergic interneurons in the nucleus accumbensCorey Baimel0Emily Jang1Samantha L. Scudder2Kasra Manoocheri3Adam G. Carter4Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USACenter for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USACenter for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USACenter for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USACenter for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA; Corresponding authorSummary: Cholinergic interneurons (ChIs) in the nucleus accumbens (NAc) play a central role in motivated behaviors and associated disorders. However, while the activation of ChIs has been well studied in the dorsal striatum, little is known about how they are engaged in the NAc. Here, we find that the ventral hippocampus (vHPC) and the paraventricular nucleus of the thalamus (PVT) are the main excitatory inputs to ChIs in the NAc medial shell. While the PVT activates ChIs, the vHPC evokes a pronounced pause in firing through prominent feedforward inhibition. In contrast to the dorsal striatum, this inhibition reflects strong connections onto ChIs from local parvalbumin interneurons. Our results reveal the mechanisms by which different long-range inputs engage ChIs, highlighting fundamental differences in local connectivity across the striatum.http://www.sciencedirect.com/science/article/pii/S2211124722008361CP: Neuroscience |
| spellingShingle | Corey Baimel Emily Jang Samantha L. Scudder Kasra Manoocheri Adam G. Carter Hippocampal-evoked inhibition of cholinergic interneurons in the nucleus accumbens Cell Reports CP: Neuroscience |
| title | Hippocampal-evoked inhibition of cholinergic interneurons in the nucleus accumbens |
| title_full | Hippocampal-evoked inhibition of cholinergic interneurons in the nucleus accumbens |
| title_fullStr | Hippocampal-evoked inhibition of cholinergic interneurons in the nucleus accumbens |
| title_full_unstemmed | Hippocampal-evoked inhibition of cholinergic interneurons in the nucleus accumbens |
| title_short | Hippocampal-evoked inhibition of cholinergic interneurons in the nucleus accumbens |
| title_sort | hippocampal evoked inhibition of cholinergic interneurons in the nucleus accumbens |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124722008361 |
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