The Marine-Derived Kinase Inhibitor Fascaplysin Exerts Anti-Thrombotic Activity

The Marine-Derived Kinase Inhibitor Fascaplysin Exerts Anti-Thrombotic Activity

Background: The marine-derived kinase inhibitor fascaplysin down-regulates the PI3K pathway in cancer cells. Since this pathway also plays an essential role in platelet signaling, we herein investigated the effect of fascaplysin on thrombosis. Methods: Fascaplysin effects on platelet activation, pla...

Full description

Bibliographic Details
Main Authors: Emmanuel Ampofo, Thomas Später, Isabelle Müller, Hermann Eichler, Michael D. Menger, Matthias W. Laschke
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:Marine Drugs
Subjects:
fascaplysin
thrombosis
platelets
GPIIb/IIIa
P-selectin
leukocytes
CD11b
dorsal skinfold chamber
Online Access:http://www.mdpi.com/1660-3397/13/11/6774

Internet

http://www.mdpi.com/1660-3397/13/11/6774

Similar Items