First evidence on the causal association between green tea and gastrointestinal health: a two sample mendelian randomization study
ABSTRACTIn light of the persisting ambiguity surrounding the causality between green tea intake and gastrointestinal health, this study endeavors to elucidate it using mendelian randomization. Leveraging data from the UK Biobank and FinnGen database, instrumental variants were selected from single-n...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
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| Series: | CyTA - Journal of Food |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19476337.2024.2308628 |
| _version_ | 1797337620782514176 |
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| author | Zhixiong Jiang Renlan Li Yi Li |
| author_facet | Zhixiong Jiang Renlan Li Yi Li |
| author_sort | Zhixiong Jiang |
| collection | DOAJ |
| description | ABSTRACTIn light of the persisting ambiguity surrounding the causality between green tea intake and gastrointestinal health, this study endeavors to elucidate it using mendelian randomization. Leveraging data from the UK Biobank and FinnGen database, instrumental variants were selected from single-nucleotide-polymorphisms associated with green tea intake. The inverse-variance-weighted method served as the primary analytical approach. Rigorous scrutiny of the results encompassed the Egger intercept test, Mendelian Randomization Presso, Cochran Q test, leave-one-out test, and funnel plot. The primary findings underscore a significant association between green tea intake and gastrointestinal diseases (p = 0.001), indicating heightened consumption of green tea could lead to a reduced risk of gastrointestinal diseases (odds ratio = 0.994). Robustness assessments across all measures substantiate the credibility of these outcomes (all p > 0.05). In conclusion, this study supports the assertion that green tea confers beneficial effects on gastrointestinal health. |
| first_indexed | 2024-03-08T09:16:16Z |
| format | Article |
| id | doaj.art-82f9e69ee17e4b97849603d209020587 |
| institution | Directory Open Access Journal |
| issn | 1947-6337 1947-6345 |
| language | English |
| last_indexed | 2024-03-08T09:16:16Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CyTA - Journal of Food |
| spelling | doaj.art-82f9e69ee17e4b97849603d2090205872024-01-31T16:17:39ZengTaylor & Francis GroupCyTA - Journal of Food1947-63371947-63452024-12-0122110.1080/19476337.2024.2308628First evidence on the causal association between green tea and gastrointestinal health: a two sample mendelian randomization studyZhixiong Jiang0Renlan Li1Yi Li2Department of Nutrition, The Second Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Nutrition, The Second Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Rehabilitation, Chengdu Second People’s Hospital, Chengdu, ChinaABSTRACTIn light of the persisting ambiguity surrounding the causality between green tea intake and gastrointestinal health, this study endeavors to elucidate it using mendelian randomization. Leveraging data from the UK Biobank and FinnGen database, instrumental variants were selected from single-nucleotide-polymorphisms associated with green tea intake. The inverse-variance-weighted method served as the primary analytical approach. Rigorous scrutiny of the results encompassed the Egger intercept test, Mendelian Randomization Presso, Cochran Q test, leave-one-out test, and funnel plot. The primary findings underscore a significant association between green tea intake and gastrointestinal diseases (p = 0.001), indicating heightened consumption of green tea could lead to a reduced risk of gastrointestinal diseases (odds ratio = 0.994). Robustness assessments across all measures substantiate the credibility of these outcomes (all p > 0.05). In conclusion, this study supports the assertion that green tea confers beneficial effects on gastrointestinal health.https://www.tandfonline.com/doi/10.1080/19476337.2024.2308628Green teagastrointestinal diseasemendelian randomizationnutritionfood |
| spellingShingle | Zhixiong Jiang Renlan Li Yi Li First evidence on the causal association between green tea and gastrointestinal health: a two sample mendelian randomization study CyTA - Journal of Food Green tea gastrointestinal disease mendelian randomization nutrition food |
| title | First evidence on the causal association between green tea and gastrointestinal health: a two sample mendelian randomization study |
| title_full | First evidence on the causal association between green tea and gastrointestinal health: a two sample mendelian randomization study |
| title_fullStr | First evidence on the causal association between green tea and gastrointestinal health: a two sample mendelian randomization study |
| title_full_unstemmed | First evidence on the causal association between green tea and gastrointestinal health: a two sample mendelian randomization study |
| title_short | First evidence on the causal association between green tea and gastrointestinal health: a two sample mendelian randomization study |
| title_sort | first evidence on the causal association between green tea and gastrointestinal health a two sample mendelian randomization study |
| topic | Green tea gastrointestinal disease mendelian randomization nutrition food |
| url | https://www.tandfonline.com/doi/10.1080/19476337.2024.2308628 |
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