Chaperone-Assisted Mitotic Actin Remodeling by BAG3 and HSPB8 Involves the Deacetylase HDAC6 and Its Substrate Cortactin

Chaperone-Assisted Mitotic Actin Remodeling by BAG3 and HSPB8 Involves the Deacetylase HDAC6 and Its Substrate Cortactin

The fidelity of actin dynamics relies on protein quality control, but the underlying molecular mechanisms are poorly defined. During mitosis, the cochaperone BCL2-associated athanogene 3 (BAG3) modulates cell rounding, cortex stability, spindle orientation, and chromosome segregation. Mitotic BAG3 s...

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Bibliographic Details
Main Authors: Carole Luthold, Alice-Anaïs Varlet, Herman Lambert, François Bordeleau, Josée N. Lavoie
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
BAG3 1
HSPB8 2
p62/SQSTM1 3
HDAC6 4
Arp2/3 5
cortactin 6
Online Access:https://www.mdpi.com/1422-0067/22/1/142

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