Telomere Shortening and Psychiatric Disorders: A Systematic Review
Telomeres are aging biomarkers, as they shorten while cells undergo mitosis. The aim of this study was to evaluate whether psychiatric disorders marked by psychological distress lead to alterations to telomere length (TL), corroborating the hypothesis that mental disorders might have a deeper impact...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/6/1423 |
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| author | Pedro A. Pousa Raquel M. Souza Paulo Henrique M. Melo Bernardo H. M. Correa Tamires S. C. Mendonça Ana Cristina Simões-e-Silva Débora M. Miranda |
| author_facet | Pedro A. Pousa Raquel M. Souza Paulo Henrique M. Melo Bernardo H. M. Correa Tamires S. C. Mendonça Ana Cristina Simões-e-Silva Débora M. Miranda |
| author_sort | Pedro A. Pousa |
| collection | DOAJ |
| description | Telomeres are aging biomarkers, as they shorten while cells undergo mitosis. The aim of this study was to evaluate whether psychiatric disorders marked by psychological distress lead to alterations to telomere length (TL), corroborating the hypothesis that mental disorders might have a deeper impact on our physiology and aging than it was previously thought. A systematic search of the literature using MeSH descriptors of psychological distress (“Traumatic Stress Disorder” or “Anxiety Disorder” or “depression”) and telomere length (“cellular senescence”, “oxidative stress” and “telomere”) was conducted on PubMed, Cochrane Library and ScienceDirect databases. A total of 56 studies (113,699 patients) measured the TL from individuals diagnosed with anxiety, depression and posttraumatic disorders and compared them with those from healthy subjects. Overall, TL negatively associates with distress-related mental disorders. The possible underlying molecular mechanisms that underly psychiatric diseases to telomere shortening include oxidative stress, inflammation and mitochondrial dysfunction linking. It is still unclear whether psychological distress is either a cause or a consequence of telomere shortening. |
| first_indexed | 2024-03-10T10:38:09Z |
| format | Article |
| id | doaj.art-82fd2b8c8b014a44847e93147b00c4f5 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T10:38:09Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-82fd2b8c8b014a44847e93147b00c4f52023-11-21T23:10:33ZengMDPI AGCells2073-44092021-06-01106142310.3390/cells10061423Telomere Shortening and Psychiatric Disorders: A Systematic ReviewPedro A. Pousa0Raquel M. Souza1Paulo Henrique M. Melo2Bernardo H. M. Correa3Tamires S. C. Mendonça4Ana Cristina Simões-e-Silva5Débora M. Miranda6Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais 30130-100, BrazilInterdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais 30130-100, BrazilInterdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais 30130-100, BrazilInterdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais 30130-100, BrazilInterdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais 30130-100, BrazilInterdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais 30130-100, BrazilDepartment of Pediatrics, Laboratory of Molecular Medicine, UFMG, Belo Horizonte, Minas Gerais 30130-100, BrazilTelomeres are aging biomarkers, as they shorten while cells undergo mitosis. The aim of this study was to evaluate whether psychiatric disorders marked by psychological distress lead to alterations to telomere length (TL), corroborating the hypothesis that mental disorders might have a deeper impact on our physiology and aging than it was previously thought. A systematic search of the literature using MeSH descriptors of psychological distress (“Traumatic Stress Disorder” or “Anxiety Disorder” or “depression”) and telomere length (“cellular senescence”, “oxidative stress” and “telomere”) was conducted on PubMed, Cochrane Library and ScienceDirect databases. A total of 56 studies (113,699 patients) measured the TL from individuals diagnosed with anxiety, depression and posttraumatic disorders and compared them with those from healthy subjects. Overall, TL negatively associates with distress-related mental disorders. The possible underlying molecular mechanisms that underly psychiatric diseases to telomere shortening include oxidative stress, inflammation and mitochondrial dysfunction linking. It is still unclear whether psychological distress is either a cause or a consequence of telomere shortening.https://www.mdpi.com/2073-4409/10/6/1423psychological distresstelomeretraumatic stress disorderdepressionanxiety |
| spellingShingle | Pedro A. Pousa Raquel M. Souza Paulo Henrique M. Melo Bernardo H. M. Correa Tamires S. C. Mendonça Ana Cristina Simões-e-Silva Débora M. Miranda Telomere Shortening and Psychiatric Disorders: A Systematic Review Cells psychological distress telomere traumatic stress disorder depression anxiety |
| title | Telomere Shortening and Psychiatric Disorders: A Systematic Review |
| title_full | Telomere Shortening and Psychiatric Disorders: A Systematic Review |
| title_fullStr | Telomere Shortening and Psychiatric Disorders: A Systematic Review |
| title_full_unstemmed | Telomere Shortening and Psychiatric Disorders: A Systematic Review |
| title_short | Telomere Shortening and Psychiatric Disorders: A Systematic Review |
| title_sort | telomere shortening and psychiatric disorders a systematic review |
| topic | psychological distress telomere traumatic stress disorder depression anxiety |
| url | https://www.mdpi.com/2073-4409/10/6/1423 |
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