CD4+ T-cell DNA methylation changes during pregnancy significantly correlate with disease-associated methylation changes in autoimmune diseases

CD4+ T-cell DNA methylation changes during pregnancy significantly correlate with disease-associated methylation changes in autoimmune diseases

Epigenetics may play a central, yet unexplored, role in the profound changes that the maternal immune system undergoes during pregnancy and could be involved in the pregnancy-induced modulation of several autoimmune diseases. We investigated changes in the methylome in isolated circulating CD4+ T-ce...

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Bibliographic Details
Main Authors: Tejaswi V. Badam, Sandra Hellberg, Ratnesh B. Mehta, Jeannette Lechner-Scott, Rodney A. Lea, Jorg Tost, Xavier Mariette, Judit Svensson-Arvelund, Colm E. Nestor, Mikael Benson, Göran Berg, Maria C. Jenmalm, Mika Gustafsson, Jan Ernerudh
Format: Article
Language:English
Published: Taylor & Francis Group 2022-09-01
Series:Epigenetics
Subjects:
pregnancy
epigenetics
methylation
cd4+ t cells
module
rheumatoid arthritis
multiple sclerosis
systemic lupus erythematosus
Online Access:http://dx.doi.org/10.1080/15592294.2021.1982510

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