The correlation between serum selenium, zinc, and COVID-19 severity: an observational study
Abstract Background Without an adequate immune response, SARS-CoV2 virus can simply spread throughout the body of the host. Two of the well-known immunonutrients are selenium (Se) and zinc (Zn). Se and Zn deficiency might lead to inflammation, oxidative stress, and viral entry into the cells by decr...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-021-06617-3 |
| _version_ | 1818577356646776832 |
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| author | Soodeh Razeghi Jahromi Hedieh Moradi Tabriz Mansoureh Togha Shadi Ariyanfar Zeinab Ghorbani Sima Naeeni Samaneh Haghighi Aboozar Jazayeri Mahnaz Montazeri Mohammad Talebpour Haleh Ashraf Mehdi Ebrahimi Azita Hekmatdoost Elham Jafari |
| author_facet | Soodeh Razeghi Jahromi Hedieh Moradi Tabriz Mansoureh Togha Shadi Ariyanfar Zeinab Ghorbani Sima Naeeni Samaneh Haghighi Aboozar Jazayeri Mahnaz Montazeri Mohammad Talebpour Haleh Ashraf Mehdi Ebrahimi Azita Hekmatdoost Elham Jafari |
| author_sort | Soodeh Razeghi Jahromi |
| collection | DOAJ |
| description | Abstract Background Without an adequate immune response, SARS-CoV2 virus can simply spread throughout the body of the host. Two of the well-known immunonutrients are selenium (Se) and zinc (Zn). Se and Zn deficiency might lead to inflammation, oxidative stress, and viral entry into the cells by decreasing ACE-2 expression; three factors that are proposed to be involved in COVID-19 pathogenesis. Thus, in the current study we aimed at evaluating the correlation between serum Se and Zn status and COVID-19 severity. Methods Eighty-four COVID-19 patients were enrolled in this observational study. Patients were diagnosed based on an infectious disease specialist diagnosis, using WHO interim guidance and the recommendations of the Iranian National Committee of Covid-19. The patients with acute respiratory tract infection symptoms were checked for compatibility of chest computed tomography (CT) scan results with that of Covid-19 and Real-time polymerase chain reaction (RT-PCR) for corona virus infection. The severity of Covid-19 was categorized into three groups (mild, moderate, and severe) using CDC criteria. Serum Zn and Se level of all subjects was measured. The severity of the disease was determined only once at the onset of disease. Results According to the results of linear regression test, there was a significant association between Zn and Se level and COVID-19 severity (β = − 0.28, P-value = 0.01 for Se; β = − 0.26, P-value = 0.02). However the significance disappeared after adjusting for confounding factors. Spearman correlation analysis showed a significant negative association between serum Zn, Se and CRP level (r = − 0.35, P-value = 0.001 for Se; r = − 0.41, P-value < 0.001 for Zn). Conclusion Results suggest that increasing levels of Se and Zn were accompanied by a decrease in serum CRP level. However, the significant association between Se, Zn, and disease severity was lost after adjusting for confounding factors. |
| first_indexed | 2024-12-16T06:28:37Z |
| format | Article |
| id | doaj.art-82ff13b3dd2e45888a662e3e11d69235 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-16T06:28:37Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-82ff13b3dd2e45888a662e3e11d692352022-12-21T22:40:56ZengBMCBMC Infectious Diseases1471-23342021-09-012111910.1186/s12879-021-06617-3The correlation between serum selenium, zinc, and COVID-19 severity: an observational studySoodeh Razeghi Jahromi0Hedieh Moradi Tabriz1Mansoureh Togha2Shadi Ariyanfar3Zeinab Ghorbani4Sima Naeeni5Samaneh Haghighi6Aboozar Jazayeri7Mahnaz Montazeri8Mohammad Talebpour9Haleh Ashraf10Mehdi Ebrahimi11Azita Hekmatdoost12Elham Jafari13Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical SciencesDepartment of Pathology, Sina Hospital, Tehran University of Medical SciencesHeadache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical SciencesDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical SciencesCardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical SciencesNeurology ward, Sina Hospital, Tehran University of Medical SciencesHeadache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical SciencesHeadache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical SciencesDepartment of Infectious Diseases, Sina Hospital, Tehran University of Medical SciencesDepartment of Surgery, Sina Hospital, Tehran University of Medical SciencesResearch Development Center, Sina Hospital, Tehran University of Medical SciencesEndocrinology Department, Sina Hospital, Tehran University of Medical SciencesDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical SciencesHeadache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical SciencesAbstract Background Without an adequate immune response, SARS-CoV2 virus can simply spread throughout the body of the host. Two of the well-known immunonutrients are selenium (Se) and zinc (Zn). Se and Zn deficiency might lead to inflammation, oxidative stress, and viral entry into the cells by decreasing ACE-2 expression; three factors that are proposed to be involved in COVID-19 pathogenesis. Thus, in the current study we aimed at evaluating the correlation between serum Se and Zn status and COVID-19 severity. Methods Eighty-four COVID-19 patients were enrolled in this observational study. Patients were diagnosed based on an infectious disease specialist diagnosis, using WHO interim guidance and the recommendations of the Iranian National Committee of Covid-19. The patients with acute respiratory tract infection symptoms were checked for compatibility of chest computed tomography (CT) scan results with that of Covid-19 and Real-time polymerase chain reaction (RT-PCR) for corona virus infection. The severity of Covid-19 was categorized into three groups (mild, moderate, and severe) using CDC criteria. Serum Zn and Se level of all subjects was measured. The severity of the disease was determined only once at the onset of disease. Results According to the results of linear regression test, there was a significant association between Zn and Se level and COVID-19 severity (β = − 0.28, P-value = 0.01 for Se; β = − 0.26, P-value = 0.02). However the significance disappeared after adjusting for confounding factors. Spearman correlation analysis showed a significant negative association between serum Zn, Se and CRP level (r = − 0.35, P-value = 0.001 for Se; r = − 0.41, P-value < 0.001 for Zn). Conclusion Results suggest that increasing levels of Se and Zn were accompanied by a decrease in serum CRP level. However, the significant association between Se, Zn, and disease severity was lost after adjusting for confounding factors.https://doi.org/10.1186/s12879-021-06617-3COVID-19ZincSeleniumNutritional statusImmunity |
| spellingShingle | Soodeh Razeghi Jahromi Hedieh Moradi Tabriz Mansoureh Togha Shadi Ariyanfar Zeinab Ghorbani Sima Naeeni Samaneh Haghighi Aboozar Jazayeri Mahnaz Montazeri Mohammad Talebpour Haleh Ashraf Mehdi Ebrahimi Azita Hekmatdoost Elham Jafari The correlation between serum selenium, zinc, and COVID-19 severity: an observational study BMC Infectious Diseases COVID-19 Zinc Selenium Nutritional status Immunity |
| title | The correlation between serum selenium, zinc, and COVID-19 severity: an observational study |
| title_full | The correlation between serum selenium, zinc, and COVID-19 severity: an observational study |
| title_fullStr | The correlation between serum selenium, zinc, and COVID-19 severity: an observational study |
| title_full_unstemmed | The correlation between serum selenium, zinc, and COVID-19 severity: an observational study |
| title_short | The correlation between serum selenium, zinc, and COVID-19 severity: an observational study |
| title_sort | correlation between serum selenium zinc and covid 19 severity an observational study |
| topic | COVID-19 Zinc Selenium Nutritional status Immunity |
| url | https://doi.org/10.1186/s12879-021-06617-3 |
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