The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions
Based on a working fluid consisting of a poorly water-soluble drug and a pharmaceutical polymer in an organic solvent, electrospinning has been widely exploited to create a variety of amorphous solid dispersions However, there have been very few reports about how to prepare the working fluid in a re...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1184767/full |
| _version_ | 1827950630841352192 |
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| author | Haibin Wang Yingying Lu Haisong Yang Deng-Guang Yu Xuhua Lu |
| author_facet | Haibin Wang Yingying Lu Haisong Yang Deng-Guang Yu Xuhua Lu |
| author_sort | Haibin Wang |
| collection | DOAJ |
| description | Based on a working fluid consisting of a poorly water-soluble drug and a pharmaceutical polymer in an organic solvent, electrospinning has been widely exploited to create a variety of amorphous solid dispersions However, there have been very few reports about how to prepare the working fluid in a reasonable manner. In this study, an investigation was conducted to determine the influences of ultrasonic fluid pretreatment on the quality of resultant ASDs fabricated from the working fluids. SEM results demonstrated that nanofiber-based amorphous solid dispersions from the treated fluids treated amorphous solid dispersions exhibited better quality than the traditional nanofibers from untreated fluids in the following aspects: 1) a straighter linear morphology; 2) a smooth surface; and 3) a more evener diameter distribution. The fabrication mechanism associated with the influences of ultrasonic treatments of working fluids on the resultant nanofibers’ quality is suggested. Although XRD and ATR–FTIR experiments clearly verified that the drug ketoprofen was homogeneously distributed all over the TASDs and the traditional nanofibers in an amorphous state regardless of the ultrasonic treatments, the in vitro dissolution tests clearly demonstrated that the TASDs had a better sustained drug release performance than the traditional nanofibers in terms of the initial release rate and the sustained release time periods. |
| first_indexed | 2024-04-09T13:29:43Z |
| format | Article |
| id | doaj.art-82ff3ee9b0aa46298f75572599f2035e |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-09T13:29:43Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-82ff3ee9b0aa46298f75572599f2035e2023-05-10T04:56:40ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-05-011010.3389/fmolb.2023.11847671184767The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersionsHaibin Wang0Yingying Lu1Haisong Yang2Deng-Guang Yu3Xuhua Lu4Department of Orthopaedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, ChinaObstetrics and Gynecology Hospital, Fudan University, Shanghai, ChinaDepartment of Orthopaedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, ChinaDepartment of Orthopaedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, ChinaBased on a working fluid consisting of a poorly water-soluble drug and a pharmaceutical polymer in an organic solvent, electrospinning has been widely exploited to create a variety of amorphous solid dispersions However, there have been very few reports about how to prepare the working fluid in a reasonable manner. In this study, an investigation was conducted to determine the influences of ultrasonic fluid pretreatment on the quality of resultant ASDs fabricated from the working fluids. SEM results demonstrated that nanofiber-based amorphous solid dispersions from the treated fluids treated amorphous solid dispersions exhibited better quality than the traditional nanofibers from untreated fluids in the following aspects: 1) a straighter linear morphology; 2) a smooth surface; and 3) a more evener diameter distribution. The fabrication mechanism associated with the influences of ultrasonic treatments of working fluids on the resultant nanofibers’ quality is suggested. Although XRD and ATR–FTIR experiments clearly verified that the drug ketoprofen was homogeneously distributed all over the TASDs and the traditional nanofibers in an amorphous state regardless of the ultrasonic treatments, the in vitro dissolution tests clearly demonstrated that the TASDs had a better sustained drug release performance than the traditional nanofibers in terms of the initial release rate and the sustained release time periods.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1184767/fullblending electrospinningnanocompositesultrasonic treatmentsworking fluidsamorphous solid dispersions |
| spellingShingle | Haibin Wang Yingying Lu Haisong Yang Deng-Guang Yu Xuhua Lu The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions Frontiers in Molecular Biosciences blending electrospinning nanocomposites ultrasonic treatments working fluids amorphous solid dispersions |
| title | The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions |
| title_full | The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions |
| title_fullStr | The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions |
| title_full_unstemmed | The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions |
| title_short | The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions |
| title_sort | influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions |
| topic | blending electrospinning nanocomposites ultrasonic treatments working fluids amorphous solid dispersions |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1184767/full |
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