Nisin Variants Generated by Protein Engineering and Their Properties
Nisin, a typical lantibiotic, has robust antimicrobial activity combined with limited cytotoxicity, and the development of resistance to it is slow. These properties make nisin a promising antimicrobial agent to control pathogenic microorganisms in dairy foods. However, its low solubility, poor stab...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/9/6/251 |
| _version_ | 1797489877366865920 |
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| author | Yue Zheng Yuhui Du Zekai Qiu Ziming Liu Jianjun Qiao Yanni Li Qinggele Caiyin |
| author_facet | Yue Zheng Yuhui Du Zekai Qiu Ziming Liu Jianjun Qiao Yanni Li Qinggele Caiyin |
| author_sort | Yue Zheng |
| collection | DOAJ |
| description | Nisin, a typical lantibiotic, has robust antimicrobial activity combined with limited cytotoxicity, and the development of resistance to it is slow. These properties make nisin a promising antimicrobial agent to control pathogenic microorganisms in dairy foods. However, its low solubility, poor stability and short half-life at neutral pH limit its application within the dairy industry. Protein engineering technology has revealed the potential of modifying nisin to improve its properties, and many valuable variants have emerged. This review summarizes progress in the generation of nisin variants for the dairy industry and for other purposes. These nisin variants with additional modification have improved properties and can even expand the inhibition spectrum range of nisin. Nisin, as the most thoroughly studied lantibiotic, and its variants can also guide the modification of other lantibiotics. |
| first_indexed | 2024-03-10T00:23:52Z |
| format | Article |
| id | doaj.art-83006df07d3142d8a657c2bd2f739242 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T00:23:52Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-83006df07d3142d8a657c2bd2f7392422023-11-23T15:38:05ZengMDPI AGBioengineering2306-53542022-06-019625110.3390/bioengineering9060251Nisin Variants Generated by Protein Engineering and Their PropertiesYue Zheng0Yuhui Du1Zekai Qiu2Ziming Liu3Jianjun Qiao4Yanni Li5Qinggele Caiyin6School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaMOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, ChinaSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaNisin, a typical lantibiotic, has robust antimicrobial activity combined with limited cytotoxicity, and the development of resistance to it is slow. These properties make nisin a promising antimicrobial agent to control pathogenic microorganisms in dairy foods. However, its low solubility, poor stability and short half-life at neutral pH limit its application within the dairy industry. Protein engineering technology has revealed the potential of modifying nisin to improve its properties, and many valuable variants have emerged. This review summarizes progress in the generation of nisin variants for the dairy industry and for other purposes. These nisin variants with additional modification have improved properties and can even expand the inhibition spectrum range of nisin. Nisin, as the most thoroughly studied lantibiotic, and its variants can also guide the modification of other lantibiotics.https://www.mdpi.com/2306-5354/9/6/251nisinantibioticsbioengineeringdairy preservation |
| spellingShingle | Yue Zheng Yuhui Du Zekai Qiu Ziming Liu Jianjun Qiao Yanni Li Qinggele Caiyin Nisin Variants Generated by Protein Engineering and Their Properties Bioengineering nisin antibiotics bioengineering dairy preservation |
| title | Nisin Variants Generated by Protein Engineering and Their Properties |
| title_full | Nisin Variants Generated by Protein Engineering and Their Properties |
| title_fullStr | Nisin Variants Generated by Protein Engineering and Their Properties |
| title_full_unstemmed | Nisin Variants Generated by Protein Engineering and Their Properties |
| title_short | Nisin Variants Generated by Protein Engineering and Their Properties |
| title_sort | nisin variants generated by protein engineering and their properties |
| topic | nisin antibiotics bioengineering dairy preservation |
| url | https://www.mdpi.com/2306-5354/9/6/251 |
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