Insights Into Non-coding RNAs as Novel Antimicrobial Drugs
Multidrug resistant bacteria are a serious worldwide problem, especially carbapenem-resistant Enterobacteriaceae (such as Klebsiella pneumoniae and Escherichia coli), Acinetobacter baumannii and Pseudomonas aeruginosa. Since the emergence of extensive and pan-drug resistant bacteria there are few an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fgene.2019.00057/full |
| _version_ | 1818262290865061888 |
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| author | Gisela Parmeciano Di Noto María Carolina Molina Cecilia Quiroga |
| author_facet | Gisela Parmeciano Di Noto María Carolina Molina Cecilia Quiroga |
| author_sort | Gisela Parmeciano Di Noto |
| collection | DOAJ |
| description | Multidrug resistant bacteria are a serious worldwide problem, especially carbapenem-resistant Enterobacteriaceae (such as Klebsiella pneumoniae and Escherichia coli), Acinetobacter baumannii and Pseudomonas aeruginosa. Since the emergence of extensive and pan-drug resistant bacteria there are few antibiotics left to treat patients, thus novel RNA-based strategies are being considered. Here, we examine the current situation of different non-coding RNAs found in bacteria as well as their function and potential application as antimicrobial agents. Furthermore, we discuss the factors that may contribute in the efficient development of RNA-based drugs, the limitations for their implementation and the use of nanocarriers for delivery. |
| first_indexed | 2024-12-12T19:00:47Z |
| format | Article |
| id | doaj.art-8300a707c4e44551b65f3fb0d0c04abb |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-12T19:00:47Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-8300a707c4e44551b65f3fb0d0c04abb2022-12-22T00:15:06ZengFrontiers Media S.A.Frontiers in Genetics1664-80212019-02-011010.3389/fgene.2019.00057426351Insights Into Non-coding RNAs as Novel Antimicrobial DrugsGisela Parmeciano Di NotoMaría Carolina MolinaCecilia QuirogaMultidrug resistant bacteria are a serious worldwide problem, especially carbapenem-resistant Enterobacteriaceae (such as Klebsiella pneumoniae and Escherichia coli), Acinetobacter baumannii and Pseudomonas aeruginosa. Since the emergence of extensive and pan-drug resistant bacteria there are few antibiotics left to treat patients, thus novel RNA-based strategies are being considered. Here, we examine the current situation of different non-coding RNAs found in bacteria as well as their function and potential application as antimicrobial agents. Furthermore, we discuss the factors that may contribute in the efficient development of RNA-based drugs, the limitations for their implementation and the use of nanocarriers for delivery.https://www.frontiersin.org/article/10.3389/fgene.2019.00057/fullsRNACRISPR-CasantimicrobialRNAdelivery |
| spellingShingle | Gisela Parmeciano Di Noto María Carolina Molina Cecilia Quiroga Insights Into Non-coding RNAs as Novel Antimicrobial Drugs Frontiers in Genetics sRNA CRISPR-Cas antimicrobial RNA delivery |
| title | Insights Into Non-coding RNAs as Novel Antimicrobial Drugs |
| title_full | Insights Into Non-coding RNAs as Novel Antimicrobial Drugs |
| title_fullStr | Insights Into Non-coding RNAs as Novel Antimicrobial Drugs |
| title_full_unstemmed | Insights Into Non-coding RNAs as Novel Antimicrobial Drugs |
| title_short | Insights Into Non-coding RNAs as Novel Antimicrobial Drugs |
| title_sort | insights into non coding rnas as novel antimicrobial drugs |
| topic | sRNA CRISPR-Cas antimicrobial RNA delivery |
| url | https://www.frontiersin.org/article/10.3389/fgene.2019.00057/full |
| work_keys_str_mv | AT giselaparmecianodinoto insightsintononcodingrnasasnovelantimicrobialdrugs AT mariacarolinamolina insightsintononcodingrnasasnovelantimicrobialdrugs AT ceciliaquiroga insightsintononcodingrnasasnovelantimicrobialdrugs |