Posterior white matter integrity and self-reported posterior cortical symptoms using the Colorado Posterior Cortical Questionnaire
BackgroundThe Colorado Posterior Cortical Questionnaire (CPC-Q) is a self-report, 15-item screening questionnaire for posterior cortical symptoms, including visuospatial and visuoperceptual difficulties. Changes in white matter connectivity may precede obvious gray matter atrophy in neurodegenerativ...
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1072938/full |
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| author | Samantha K. Holden Samantha K. Holden Samantha K. Holden Brianne M. Bettcher Brianne M. Bettcher Christopher M. Filley Christopher M. Filley Christopher M. Filley Christopher M. Filley Dan Lopez-Paniagua Victoria S. Pelak Victoria S. Pelak Victoria S. Pelak |
| author_facet | Samantha K. Holden Samantha K. Holden Samantha K. Holden Brianne M. Bettcher Brianne M. Bettcher Christopher M. Filley Christopher M. Filley Christopher M. Filley Christopher M. Filley Dan Lopez-Paniagua Victoria S. Pelak Victoria S. Pelak Victoria S. Pelak |
| author_sort | Samantha K. Holden |
| collection | DOAJ |
| description | BackgroundThe Colorado Posterior Cortical Questionnaire (CPC-Q) is a self-report, 15-item screening questionnaire for posterior cortical symptoms, including visuospatial and visuoperceptual difficulties. Changes in white matter connectivity may precede obvious gray matter atrophy in neurodegenerative conditions, especially posterior cortical atrophy. Integration of CPC-Q scores and measures of white matter integrity could contribute to earlier detection of posterior cortical syndromes.MethodsWe investigated the relationships between posterior cortical symptoms as captured by the CPC-Q and diffusion tensor imaging fractional anisotropy (DTI FA) of white matter regions of interest localized to posterior brain regions (posterior thalamic radiations, splenium of corpus callosum, tapetum). Comparisons were also made by diagnostic group [healthy older adult (n = 31), amnestic Alzheimer's disease (AD, n = 18), and posterior cortical atrophy (PCA, n = 9)] and by SENAS battery visuospatial composite score quartile. Exploratory comparisons of all available individual white matter region DTI FA to CPC-Q, as well as comparisons of DTI FA between diagnostic groups and visuospatial quartiles, were also made.ResultsCPC-Q score was correlated with the average DTI FA for the averaged posterior white matter regions of interest (r = −0.31, p = 0.02). Posterior thalamic radiation DTI FA was most strongly associated with CPC-Q (r = −0.34, p = 0.01) and visuospatial composite (r = 0.58, p < 0.01) scores and differed between the PCA and AD groups and the lower and higher visuospatial quartiles. The DTI FA of body and splenium of the corpus callosum also demonstrated this pattern but not the DTI FA of the tapetum.ConclusionThe integrity of posterior white matter tracts is associated with scores on the CPC-Q, adding to the validation evidence for this new questionnaire. White matter regions that may be related to posterior cortical symptoms detected by the CPC-Q, and distinct from those affected in amnestic syndromes, include the posterior thalamic radiations and body and splenium of the corpus callosum. These findings are in line with previous neuroimaging studies of PCA and support continued research on white matter in posterior cortical dysfunction. |
| first_indexed | 2024-04-10T18:48:19Z |
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| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T18:48:19Z |
| publishDate | 2023-02-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-83015d17af384ae1a1e5701402ba98732023-02-01T08:39:33ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-02-011410.3389/fneur.2023.10729381072938Posterior white matter integrity and self-reported posterior cortical symptoms using the Colorado Posterior Cortical QuestionnaireSamantha K. Holden0Samantha K. Holden1Samantha K. Holden2Brianne M. Bettcher3Brianne M. Bettcher4Christopher M. Filley5Christopher M. Filley6Christopher M. Filley7Christopher M. Filley8Dan Lopez-Paniagua9Victoria S. Pelak10Victoria S. Pelak11Victoria S. Pelak12Department of Neurology, University of Colorado School of Medicine, Aurora, CO, United StatesDepartment of Neurology, Behavioral Neurology Section, University of Colorado School of Medicine, Aurora, CO, United StatesDepartment of Neurology, Movement Disorders Section, University of Colorado School of Medicine, Aurora, CO, United StatesDepartment of Neurology, University of Colorado School of Medicine, Aurora, CO, United StatesDepartment of Neurology, Behavioral Neurology Section, University of Colorado School of Medicine, Aurora, CO, United StatesDepartment of Neurology, University of Colorado School of Medicine, Aurora, CO, United StatesDepartment of Neurology, Behavioral Neurology Section, University of Colorado School of Medicine, Aurora, CO, United StatesDepartment of Psychiatry, University of Colorado School of Medicine, Aurora, CO, United StatesMarcus Institute for Brain Health, Aurora, CO, United StatesDepartment of Radiology, University of Colorado School of Medicine, Aurora, CO, United StatesDepartment of Neurology, University of Colorado School of Medicine, Aurora, CO, United StatesDepartment of Neurology, Behavioral Neurology Section, University of Colorado School of Medicine, Aurora, CO, United StatesDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, United StatesBackgroundThe Colorado Posterior Cortical Questionnaire (CPC-Q) is a self-report, 15-item screening questionnaire for posterior cortical symptoms, including visuospatial and visuoperceptual difficulties. Changes in white matter connectivity may precede obvious gray matter atrophy in neurodegenerative conditions, especially posterior cortical atrophy. Integration of CPC-Q scores and measures of white matter integrity could contribute to earlier detection of posterior cortical syndromes.MethodsWe investigated the relationships between posterior cortical symptoms as captured by the CPC-Q and diffusion tensor imaging fractional anisotropy (DTI FA) of white matter regions of interest localized to posterior brain regions (posterior thalamic radiations, splenium of corpus callosum, tapetum). Comparisons were also made by diagnostic group [healthy older adult (n = 31), amnestic Alzheimer's disease (AD, n = 18), and posterior cortical atrophy (PCA, n = 9)] and by SENAS battery visuospatial composite score quartile. Exploratory comparisons of all available individual white matter region DTI FA to CPC-Q, as well as comparisons of DTI FA between diagnostic groups and visuospatial quartiles, were also made.ResultsCPC-Q score was correlated with the average DTI FA for the averaged posterior white matter regions of interest (r = −0.31, p = 0.02). Posterior thalamic radiation DTI FA was most strongly associated with CPC-Q (r = −0.34, p = 0.01) and visuospatial composite (r = 0.58, p < 0.01) scores and differed between the PCA and AD groups and the lower and higher visuospatial quartiles. The DTI FA of body and splenium of the corpus callosum also demonstrated this pattern but not the DTI FA of the tapetum.ConclusionThe integrity of posterior white matter tracts is associated with scores on the CPC-Q, adding to the validation evidence for this new questionnaire. White matter regions that may be related to posterior cortical symptoms detected by the CPC-Q, and distinct from those affected in amnestic syndromes, include the posterior thalamic radiations and body and splenium of the corpus callosum. These findings are in line with previous neuroimaging studies of PCA and support continued research on white matter in posterior cortical dysfunction.https://www.frontiersin.org/articles/10.3389/fneur.2023.1072938/fullwhite matterposterior cortexoutcome measure assessmentposterior cortical atrophy (PCA)self-report measuresdiffusion tensor imaging |
| spellingShingle | Samantha K. Holden Samantha K. Holden Samantha K. Holden Brianne M. Bettcher Brianne M. Bettcher Christopher M. Filley Christopher M. Filley Christopher M. Filley Christopher M. Filley Dan Lopez-Paniagua Victoria S. Pelak Victoria S. Pelak Victoria S. Pelak Posterior white matter integrity and self-reported posterior cortical symptoms using the Colorado Posterior Cortical Questionnaire Frontiers in Neurology white matter posterior cortex outcome measure assessment posterior cortical atrophy (PCA) self-report measures diffusion tensor imaging |
| title | Posterior white matter integrity and self-reported posterior cortical symptoms using the Colorado Posterior Cortical Questionnaire |
| title_full | Posterior white matter integrity and self-reported posterior cortical symptoms using the Colorado Posterior Cortical Questionnaire |
| title_fullStr | Posterior white matter integrity and self-reported posterior cortical symptoms using the Colorado Posterior Cortical Questionnaire |
| title_full_unstemmed | Posterior white matter integrity and self-reported posterior cortical symptoms using the Colorado Posterior Cortical Questionnaire |
| title_short | Posterior white matter integrity and self-reported posterior cortical symptoms using the Colorado Posterior Cortical Questionnaire |
| title_sort | posterior white matter integrity and self reported posterior cortical symptoms using the colorado posterior cortical questionnaire |
| topic | white matter posterior cortex outcome measure assessment posterior cortical atrophy (PCA) self-report measures diffusion tensor imaging |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1072938/full |
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