Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runners
Background Extreme exercise may alter the innate immune system. Glycans are involved in several biological processes including immune system regulation. However, limited data regarding the impact of glycan supplementation on immunological parameters after strenuous exercise are available. We aimed t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-03-01
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| Series: | Journal of the International Society of Sports Nutrition |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1186/s12970-019-0281-z |
| _version_ | 1797685022970347520 |
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| author | Emma Roca Elisabet Cantó Lexa Nescolarde Lidia Perea Antoni Bayes-Genis Oriol Sibila Silvia Vidal |
| author_facet | Emma Roca Elisabet Cantó Lexa Nescolarde Lidia Perea Antoni Bayes-Genis Oriol Sibila Silvia Vidal |
| author_sort | Emma Roca |
| collection | DOAJ |
| description | Background Extreme exercise may alter the innate immune system. Glycans are involved in several biological processes including immune system regulation. However, limited data regarding the impact of glycan supplementation on immunological parameters after strenuous exercise are available. We aimed to determine the impact of a standardized polysaccharide-based multi-ingredient supplement, Advanced Ambrotose© complex powder (AA) on salivary secretory Immunoglobulin A (sIgA) and pro- and anti-inflammatory protein levels before and after a marathon in non-elite runners. Methods Forty-one male marathon runners who completed the 42.195 km of the 2016 Barcelona marathon were randomly assigned to two study groups. Of them, n = 20 (48%) received the AA supplement for 15 days prior the race (AA group) and n = 21 (52%) did not receive any AA supplement (non-AA group). Saliva and blood samples were collected the day before the marathon and two days after the end of the race. Salivary IgA, pro-inflammatory chemokines (Gro-alpha, Gro-beta, MCP-1) and anti-inflammatory proteins (Angiogenin, ACRP, Siglec 5) were determined using commercially ELISA kits in saliva supernatant. Biochemical parameters, including C-reactive protein, cardiac biomarkers, and blood hemogram were also evaluated. Results Marathon runners who did not receive the AA supplement experienced a decrease of salivary sIgA and pro-inflammatory chemokines (Gro-alpha and Gro-beta) after the race, while runners with AA supplementation showed lower levels of anti-inflammatory chemokines (Angiogenin). Gro-alpha and Gro-beta salivary levels were lower before the race in the AA group and correlated with blood leukocytes and platelets. Conclusions Changes in salivary sIgA and inflammatory chemokines, especially Gro-alfa and Gro-beta, were observed in marathon runners supplemented with AA prior to the race. These findings suggested that AA may have a positive effect on immune response after a strenuous exercise. |
| first_indexed | 2024-03-12T00:38:20Z |
| format | Article |
| id | doaj.art-8302eb7a8142470f944b20193ea84bac |
| institution | Directory Open Access Journal |
| issn | 1550-2783 |
| language | English |
| last_indexed | 2024-03-12T00:38:20Z |
| publishDate | 2019-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of the International Society of Sports Nutrition |
| spelling | doaj.art-8302eb7a8142470f944b20193ea84bac2023-09-15T09:19:30ZengTaylor & Francis GroupJournal of the International Society of Sports Nutrition1550-27832019-03-0116110.1186/s12970-019-0281-z12130092Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runnersEmma Roca0Elisabet Cantó1Lexa Nescolarde2Lidia Perea3Antoni Bayes-Genis4Oriol Sibila5Silvia Vidal6Research Centre for Biomedical EngineeringLaboratory of Experimental Immunology, Biomedical Research Institute Sant Pau (IIB Sant Pau)Research Centre for Biomedical EngineeringLaboratory of Experimental Immunology, Biomedical Research Institute Sant Pau (IIB Sant Pau)Department of CardiologyRespiratory Department, Hospital de la Santa Creu i Sant PauLaboratory of Experimental Immunology, Biomedical Research Institute Sant Pau (IIB Sant Pau)Background Extreme exercise may alter the innate immune system. Glycans are involved in several biological processes including immune system regulation. However, limited data regarding the impact of glycan supplementation on immunological parameters after strenuous exercise are available. We aimed to determine the impact of a standardized polysaccharide-based multi-ingredient supplement, Advanced Ambrotose© complex powder (AA) on salivary secretory Immunoglobulin A (sIgA) and pro- and anti-inflammatory protein levels before and after a marathon in non-elite runners. Methods Forty-one male marathon runners who completed the 42.195 km of the 2016 Barcelona marathon were randomly assigned to two study groups. Of them, n = 20 (48%) received the AA supplement for 15 days prior the race (AA group) and n = 21 (52%) did not receive any AA supplement (non-AA group). Saliva and blood samples were collected the day before the marathon and two days after the end of the race. Salivary IgA, pro-inflammatory chemokines (Gro-alpha, Gro-beta, MCP-1) and anti-inflammatory proteins (Angiogenin, ACRP, Siglec 5) were determined using commercially ELISA kits in saliva supernatant. Biochemical parameters, including C-reactive protein, cardiac biomarkers, and blood hemogram were also evaluated. Results Marathon runners who did not receive the AA supplement experienced a decrease of salivary sIgA and pro-inflammatory chemokines (Gro-alpha and Gro-beta) after the race, while runners with AA supplementation showed lower levels of anti-inflammatory chemokines (Angiogenin). Gro-alpha and Gro-beta salivary levels were lower before the race in the AA group and correlated with blood leukocytes and platelets. Conclusions Changes in salivary sIgA and inflammatory chemokines, especially Gro-alfa and Gro-beta, were observed in marathon runners supplemented with AA prior to the race. These findings suggested that AA may have a positive effect on immune response after a strenuous exercise.http://dx.doi.org/10.1186/s12970-019-0281-zglycansdietary plant-derived polydisperse polysaccharide supplementationsalivary sigainflammatory chemokinesmarathonstrenuous exercise |
| spellingShingle | Emma Roca Elisabet Cantó Lexa Nescolarde Lidia Perea Antoni Bayes-Genis Oriol Sibila Silvia Vidal Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runners Journal of the International Society of Sports Nutrition glycans dietary plant-derived polydisperse polysaccharide supplementation salivary siga inflammatory chemokines marathon strenuous exercise |
| title | Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runners |
| title_full | Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runners |
| title_fullStr | Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runners |
| title_full_unstemmed | Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runners |
| title_short | Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runners |
| title_sort | effects of a polysaccharide based multi ingredient supplement on salivary immunity in non elite marathon runners |
| topic | glycans dietary plant-derived polydisperse polysaccharide supplementation salivary siga inflammatory chemokines marathon strenuous exercise |
| url | http://dx.doi.org/10.1186/s12970-019-0281-z |
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