The Protective Effects of Osteocyte‐Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging
Abstract Both Alzheimer's disease (AD) and osteoporosis (OP) are common age‐associated degenerative diseases and are strongly correlated with clinical epidemiology. However, there is a lack of clear pathological relationship between the brain and bone in the current understanding. Here, it is f...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-06-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202105316 |
| _version_ | 1811248014471200768 |
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| author | Ya‐Ling Jiang Zhen‐Xing Wang Xi‐Xi Liu Mei‐Dan Wan Yi‐Wei Liu Bin Jiao Xin‐Xin Liao Zhong‐Wei Luo Yi‐Yi Wang Chun‐Gu Hong Yi‐Juan Tan Ling Weng Ya‐Fang Zhou Shan‐Shan Rao Jia Cao Zheng‐Zhao Liu Teng‐Fei Wan Yuan Zhu Hui Xie Lu Shen |
| author_facet | Ya‐Ling Jiang Zhen‐Xing Wang Xi‐Xi Liu Mei‐Dan Wan Yi‐Wei Liu Bin Jiao Xin‐Xin Liao Zhong‐Wei Luo Yi‐Yi Wang Chun‐Gu Hong Yi‐Juan Tan Ling Weng Ya‐Fang Zhou Shan‐Shan Rao Jia Cao Zheng‐Zhao Liu Teng‐Fei Wan Yuan Zhu Hui Xie Lu Shen |
| author_sort | Ya‐Ling Jiang |
| collection | DOAJ |
| description | Abstract Both Alzheimer's disease (AD) and osteoporosis (OP) are common age‐associated degenerative diseases and are strongly correlated with clinical epidemiology. However, there is a lack of clear pathological relationship between the brain and bone in the current understanding. Here, it is found that young osteocyte, the most abundant cells in bone, secretes extracellular vesicles (OCYYoung‐EVs) to ameliorate cognitive impairment and the pathogenesis of AD in APP/PS1 mice and model cells. These benefits of OCYYoung‐EVs are diminished in aged osteocyte‐derived EVs (OCYAged‐EVs). Based on the self‐constructed OCY‐EVs tracer transgenic mouse models and the in vivo fluorescent imaging system, OCY‐EVs have been observed to be transported to the brain under physiological and pathological conditions. In the hippocampal administration of Aβ40 induced young AD model mice, the intramedullary injection of Rab27a‐shRNA adenovirus inhibits OCYYoung‐EVs secretion from bone and aggravates cognitive impairment. Proteomic quantitative analysis reveals that OCYYoung‐EVs, compared to OCYAged‐EVs, enrich multiple protective factors of AD pathway. The study uncovers the role of OCY‐EV as a regulator of brain health, suggesting a novel mechanism in bone‐brain communication. |
| first_indexed | 2024-04-12T15:19:41Z |
| format | Article |
| id | doaj.art-83035190eb724241a849a55944a469eb |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-12T15:19:41Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-83035190eb724241a849a55944a469eb2022-12-22T03:27:30ZengWileyAdvanced Science2198-38442022-06-01917n/an/a10.1002/advs.202105316The Protective Effects of Osteocyte‐Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with AgingYa‐Ling Jiang0Zhen‐Xing Wang1Xi‐Xi Liu2Mei‐Dan Wan3Yi‐Wei Liu4Bin Jiao5Xin‐Xin Liao6Zhong‐Wei Luo7Yi‐Yi Wang8Chun‐Gu Hong9Yi‐Juan Tan10Ling Weng11Ya‐Fang Zhou12Shan‐Shan Rao13Jia Cao14Zheng‐Zhao Liu15Teng‐Fei Wan16Yuan Zhu17Hui Xie18Lu Shen19Department of Neurology Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Orthopedics Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Neurology Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Neurology Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Orthopedics Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Neurology Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Neurology Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Orthopedics Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Orthopedics Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Orthopedics Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Orthopedics Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Neurology Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Neurology Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Orthopedics Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Orthopedics Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Orthopedics Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Orthopedics Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Neurology Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Orthopedics Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 ChinaDepartment of Neurology Xiangya Hospital Central South University Changsha Hunan 410008 ChinaAbstract Both Alzheimer's disease (AD) and osteoporosis (OP) are common age‐associated degenerative diseases and are strongly correlated with clinical epidemiology. However, there is a lack of clear pathological relationship between the brain and bone in the current understanding. Here, it is found that young osteocyte, the most abundant cells in bone, secretes extracellular vesicles (OCYYoung‐EVs) to ameliorate cognitive impairment and the pathogenesis of AD in APP/PS1 mice and model cells. These benefits of OCYYoung‐EVs are diminished in aged osteocyte‐derived EVs (OCYAged‐EVs). Based on the self‐constructed OCY‐EVs tracer transgenic mouse models and the in vivo fluorescent imaging system, OCY‐EVs have been observed to be transported to the brain under physiological and pathological conditions. In the hippocampal administration of Aβ40 induced young AD model mice, the intramedullary injection of Rab27a‐shRNA adenovirus inhibits OCYYoung‐EVs secretion from bone and aggravates cognitive impairment. Proteomic quantitative analysis reveals that OCYYoung‐EVs, compared to OCYAged‐EVs, enrich multiple protective factors of AD pathway. The study uncovers the role of OCY‐EV as a regulator of brain health, suggesting a novel mechanism in bone‐brain communication.https://doi.org/10.1002/advs.202105316agingAlzheimer's diseaseextracellular vesiclesosteocyteosteoporosis |
| spellingShingle | Ya‐Ling Jiang Zhen‐Xing Wang Xi‐Xi Liu Mei‐Dan Wan Yi‐Wei Liu Bin Jiao Xin‐Xin Liao Zhong‐Wei Luo Yi‐Yi Wang Chun‐Gu Hong Yi‐Juan Tan Ling Weng Ya‐Fang Zhou Shan‐Shan Rao Jia Cao Zheng‐Zhao Liu Teng‐Fei Wan Yuan Zhu Hui Xie Lu Shen The Protective Effects of Osteocyte‐Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging Advanced Science aging Alzheimer's disease extracellular vesicles osteocyte osteoporosis |
| title | The Protective Effects of Osteocyte‐Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging |
| title_full | The Protective Effects of Osteocyte‐Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging |
| title_fullStr | The Protective Effects of Osteocyte‐Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging |
| title_full_unstemmed | The Protective Effects of Osteocyte‐Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging |
| title_short | The Protective Effects of Osteocyte‐Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging |
| title_sort | protective effects of osteocyte derived extracellular vesicles against alzheimer s disease diminished with aging |
| topic | aging Alzheimer's disease extracellular vesicles osteocyte osteoporosis |
| url | https://doi.org/10.1002/advs.202105316 |
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