Development of Multidrug Resistance in Acute Myeloid Leukemia Is Associated with Alterations of the LPHN1/GAL-9/TIM-3 Signaling Pathway

Development of Multidrug Resistance in Acute Myeloid Leukemia Is Associated with Alterations of the LPHN1/GAL-9/TIM-3 Signaling Pathway

P-glycoprotein (known as ABCB1 transporter) expression in myeloid blasts of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) leads to the commonly observed multidrug resistance. Overexpression of latrophilin-1 was detected in leukemic cells from AML patients. In a previous study, we sh...

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Bibliographic Details
Main Authors: Zuzana Kocibalova, Martina Guzyova, Ivana Borovska, Lucia Messingerova, Lucia Copakova, Zdena Sulova, Albert Breier
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
latrophilin-1
TIM-3
galectin-9
ABCB1
CD44
acute myeloid leukemia
Online Access:https://www.mdpi.com/2072-6694/13/14/3629

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