CD4+ T Cell-Dependent Macrophage Activation Modulates Sustained PS Exposure on Intracellular Amastigotes of Leishmania amazonensis

CD4+ T Cell-Dependent Macrophage Activation Modulates Sustained PS Exposure on Intracellular Amastigotes of Leishmania amazonensis

Leishmania amazonensis amastigotes can make use of surface-exposed phosphatidylserine (PS) molecules to promote infection and non-classical activation of macrophages (MΦ), leading to uncontrolled intracellular proliferation of the parasites. This mechanism was quoted as apoptotic mimicry. Moreover,...

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Bibliographic Details
Main Authors: Joao Luiz Mendes Wanderley, Poliana Deolindo, Eric Carlsen, Arieli Bernardo Portugal, Renato Augusto DaMatta, Marcello Andre Barcinski, Lynn Soong
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
phosphatidylserine
amastigote
T cell
parasitophorous vacuole
macrophage
immune evasion
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00105/full

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