Telmisartan and cardioprotection
Philippe R Akhrass, Samy I McFarlaneState University of New York, Downstate Medical Center, Brooklyn, NY, USAAbstract: Cardiovascular risk reduction has been the target of several large clinical trials in the last decade. As the activation of the renin-angiotensin-aldosterone system (RAAS) plays a c...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2011-11-01
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| Series: | Vascular Health and Risk Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/telmisartan-and-cardioprotection-peer-reviewed-article-VHRM |
| _version_ | 1818941969801412608 |
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| author | McFarlane S |
| author_facet | McFarlane S |
| author_sort | McFarlane S |
| collection | DOAJ |
| description | Philippe R Akhrass, Samy I McFarlaneState University of New York, Downstate Medical Center, Brooklyn, NY, USAAbstract: Cardiovascular risk reduction has been the target of several large clinical trials in the last decade. As the activation of the renin-angiotensin-aldosterone system (RAAS) plays a central role in the pathogenesis of atherosclerosis and cardiovascular disease, RAAS blockade has been suggested to be among the most efficient cardioprotective interventions, as revealed with the angiotensin converting enzyme (ACE) inhibitors trials. The angiotensin receptor blockers' (ARBs) efficacy in lowering blood pressure has been very well established. Telmisartan is however the first ARB to show a promising role in reducing cardiovascular risk in high-risk patients. This article will highlight the role of telmisartan in cardioprotection, underlying specifically the results of two major randomized controlled trials: ONTARGET (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) and TRANSCEND (Telmisartan Randomized AssessmeNt Study in aCE-iNtolerant subjects with cardiovascular Disease).Keywords: telmisartan, cardioprotection, ONTARGET, TRANSCEND |
| first_indexed | 2024-12-20T07:03:59Z |
| format | Article |
| id | doaj.art-8305bc736135443c9dc5543f7845e86c |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-12-20T07:03:59Z |
| publishDate | 2011-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-8305bc736135443c9dc5543f7845e86c2022-12-21T19:49:08ZengDove Medical PressVascular Health and Risk Management1178-20482011-11-01Volume 76776838658Telmisartan and cardioprotectionMcFarlane SPhilippe R Akhrass, Samy I McFarlaneState University of New York, Downstate Medical Center, Brooklyn, NY, USAAbstract: Cardiovascular risk reduction has been the target of several large clinical trials in the last decade. As the activation of the renin-angiotensin-aldosterone system (RAAS) plays a central role in the pathogenesis of atherosclerosis and cardiovascular disease, RAAS blockade has been suggested to be among the most efficient cardioprotective interventions, as revealed with the angiotensin converting enzyme (ACE) inhibitors trials. The angiotensin receptor blockers' (ARBs) efficacy in lowering blood pressure has been very well established. Telmisartan is however the first ARB to show a promising role in reducing cardiovascular risk in high-risk patients. This article will highlight the role of telmisartan in cardioprotection, underlying specifically the results of two major randomized controlled trials: ONTARGET (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) and TRANSCEND (Telmisartan Randomized AssessmeNt Study in aCE-iNtolerant subjects with cardiovascular Disease).Keywords: telmisartan, cardioprotection, ONTARGET, TRANSCENDhttps://www.dovepress.com/telmisartan-and-cardioprotection-peer-reviewed-article-VHRMTelmisartanontargetcardio protection |
| spellingShingle | McFarlane S Telmisartan and cardioprotection Vascular Health and Risk Management Telmisartan ontarget cardio protection |
| title | Telmisartan and cardioprotection |
| title_full | Telmisartan and cardioprotection |
| title_fullStr | Telmisartan and cardioprotection |
| title_full_unstemmed | Telmisartan and cardioprotection |
| title_short | Telmisartan and cardioprotection |
| title_sort | telmisartan and cardioprotection |
| topic | Telmisartan ontarget cardio protection |
| url | https://www.dovepress.com/telmisartan-and-cardioprotection-peer-reviewed-article-VHRM |
| work_keys_str_mv | AT mcfarlanes telmisartanandcardioprotection |