Endogenous chondroitin extends the lifespan and healthspan in C. elegans

Endogenous chondroitin extends the lifespan and healthspan in C. elegans

Abstract Chondroitin, a class of glycosaminoglycan polysaccharides, is found as proteoglycans in the extracellular matrix, plays a crucial role in tissue morphogenesis during development and axonal regeneration. Ingestion of chondroitin prolongs the lifespan of C. elegans. However, the roles of endo...

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Bibliographic Details
Main Authors: Yukimasa Shibata, Yuri Tanaka, Hiroyuki Sasakura, Yuki Morioka, Toshihiro Sassa, Shion Fujii, Kaito Mitsuzumi, Masashi Ikeno, Yukihiko Kubota, Kenji Kimura, Hidenao Toyoda, Kosei Takeuchi, Kiyoji Nishiwaki
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
Aging
Chondroitin
ADAMTS protease
Basement membrane
Online Access:https://doi.org/10.1038/s41598-024-55417-7

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