Clinical significance of different bacterial load of Mycoplasma pneumoniae in patients with Mycoplasma pneumoniae pneumonia
Objective: This retrospective study was conducted to investigate the clinical significance of different Mycoplasma pneumoniae bacterial load in patients with M. pneumoniae pneumonia (MP) in children. Methods: Patients with MP (n = 511) were identified at the Children's Hospital Affiliated to So...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-03-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867013002377 |
| _version_ | 1819059880356478976 |
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| author | Wujun Jiang Yongdong Yan Wei Ji Yuqing Wang Zhengrong Chen |
| author_facet | Wujun Jiang Yongdong Yan Wei Ji Yuqing Wang Zhengrong Chen |
| author_sort | Wujun Jiang |
| collection | DOAJ |
| description | Objective: This retrospective study was conducted to investigate the clinical significance of different Mycoplasma pneumoniae bacterial load in patients with M. pneumoniae pneumonia (MP) in children. Methods: Patients with MP (n = 511) were identified at the Children's Hospital Affiliated to Soochow University database during an outbreak of MP between January 2012 and February 2013. Results: Comparing patients with high and low bacterial load those with higher loads were significantly older (p < 0.01) and had fever significantly more frequently (p = 0.01). Presence of wheezing at presentation was associated with low bacterial load (p = 0.03). Baseline positive IgM was present in 93 (56.4%) patients with high bacterial load compared to 46 (27.8%) patients with low bacterial load (p < 0.001). Co-infection with viruses was found significantly more frequent among patients with low bacterial load (24.2%) than those with high bacterial load (8.5%) [p < 0.001]. Bacterial co-infection was also more frequently detected among patients with low bacterial load (22.4%) than in those with high bacterial load (12.1%) [p = 0.01]. Conclusion: M. pneumoniae at a high bacterial load could be an etiologic agent of respiratory tract disease, whereas the etiologic role of MP at a low bacterial load remains to be determined. Keywords: Mycoplasma pneumoniae, Pneumonia, Polymerase chain reaction, Serology |
| first_indexed | 2024-12-21T14:18:07Z |
| format | Article |
| id | doaj.art-830bff3c182c435998b431c8a8b703e2 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-21T14:18:07Z |
| publishDate | 2014-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-830bff3c182c435998b431c8a8b703e22022-12-21T19:00:52ZengElsevierBrazilian Journal of Infectious Diseases1413-86702014-03-01182124128S1413-86702014000200124Clinical significance of different bacterial load of Mycoplasma pneumoniae in patients with Mycoplasma pneumoniae pneumoniaWujun Jiang0Yongdong Yan1Wei Ji2Yuqing Wang3Zhengrong Chen4Department of Respiratory Medicine, Children's Hospital Affiliated to Soochow University, ChinaCorresponding author at: The Department of Respiratory Medicine, Children's Hospital Affiliated to Soochow University, No. 303 Jing De Road, Suzhou 215003, China.; Department of Respiratory Medicine, Children's Hospital Affiliated to Soochow University, ChinaDepartment of Respiratory Medicine, Children's Hospital Affiliated to Soochow University, ChinaDepartment of Respiratory Medicine, Children's Hospital Affiliated to Soochow University, ChinaDepartment of Respiratory Medicine, Children's Hospital Affiliated to Soochow University, ChinaObjective: This retrospective study was conducted to investigate the clinical significance of different Mycoplasma pneumoniae bacterial load in patients with M. pneumoniae pneumonia (MP) in children. Methods: Patients with MP (n = 511) were identified at the Children's Hospital Affiliated to Soochow University database during an outbreak of MP between January 2012 and February 2013. Results: Comparing patients with high and low bacterial load those with higher loads were significantly older (p < 0.01) and had fever significantly more frequently (p = 0.01). Presence of wheezing at presentation was associated with low bacterial load (p = 0.03). Baseline positive IgM was present in 93 (56.4%) patients with high bacterial load compared to 46 (27.8%) patients with low bacterial load (p < 0.001). Co-infection with viruses was found significantly more frequent among patients with low bacterial load (24.2%) than those with high bacterial load (8.5%) [p < 0.001]. Bacterial co-infection was also more frequently detected among patients with low bacterial load (22.4%) than in those with high bacterial load (12.1%) [p = 0.01]. Conclusion: M. pneumoniae at a high bacterial load could be an etiologic agent of respiratory tract disease, whereas the etiologic role of MP at a low bacterial load remains to be determined. Keywords: Mycoplasma pneumoniae, Pneumonia, Polymerase chain reaction, Serologyhttp://www.sciencedirect.com/science/article/pii/S1413867013002377 |
| spellingShingle | Wujun Jiang Yongdong Yan Wei Ji Yuqing Wang Zhengrong Chen Clinical significance of different bacterial load of Mycoplasma pneumoniae in patients with Mycoplasma pneumoniae pneumonia Brazilian Journal of Infectious Diseases |
| title | Clinical significance of different bacterial load of Mycoplasma pneumoniae in patients with Mycoplasma pneumoniae pneumonia |
| title_full | Clinical significance of different bacterial load of Mycoplasma pneumoniae in patients with Mycoplasma pneumoniae pneumonia |
| title_fullStr | Clinical significance of different bacterial load of Mycoplasma pneumoniae in patients with Mycoplasma pneumoniae pneumonia |
| title_full_unstemmed | Clinical significance of different bacterial load of Mycoplasma pneumoniae in patients with Mycoplasma pneumoniae pneumonia |
| title_short | Clinical significance of different bacterial load of Mycoplasma pneumoniae in patients with Mycoplasma pneumoniae pneumonia |
| title_sort | clinical significance of different bacterial load of mycoplasma pneumoniae in patients with mycoplasma pneumoniae pneumonia |
| url | http://www.sciencedirect.com/science/article/pii/S1413867013002377 |
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