Community-associated Methicillin-Resistant Staphylococcus aureus Strains in Pediatric Intensive Care Unit
Virulent community-associated methicillin-resistant Staphylococcus-aureus (CA-MRSA) strains have spread rapidly in the United States. To characterize the degree to which CA-MRSA strains are imported into and transmitted in pediatric intensive care units (PICU), we performed a retrospective study of...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2010-04-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/16/4/09-0107_article |
| _version_ | 1818033299577110528 |
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| author | Aaron M. Milstone Karen C. Carroll Tracy Ross K. Alexander Shangraw Trish M. Perl |
| author_facet | Aaron M. Milstone Karen C. Carroll Tracy Ross K. Alexander Shangraw Trish M. Perl |
| author_sort | Aaron M. Milstone |
| collection | DOAJ |
| description | Virulent community-associated methicillin-resistant Staphylococcus-aureus (CA-MRSA) strains have spread rapidly in the United States. To characterize the degree to which CA-MRSA strains are imported into and transmitted in pediatric intensive care units (PICU), we performed a retrospective study of children admitted to The Johns Hopkins Hospital PICU, March 1, 2007–May 31, 2008. We found that 72 (6%) of 1,674 PICU patients were colonized with MRSA. MRSA-colonized patients were more likely to be younger (median age 3 years vs. 5 years; p = 0.02) and African American (p<0.001) and to have been hospitalized within 12 months (p<0.001) than were noncolonized patients. MRSA isolates from 66 (92%) colonized patients were fingerprinted; 40 (61%) were genotypically CA-MRSA strains. CA-MRSA strains were isolated from 50% of patients who became colonized with MRSA and caused the only hospital-acquired MRSA catheter-associated bloodstream infection in the cohort. Epidemic CA-MRSA strains are becoming endemic to PICUs, can be transmitted to hospitalized children, and can cause invasive hospital-acquired infections. Further appraisal of MRSA control is needed. |
| first_indexed | 2024-12-10T06:21:04Z |
| format | Article |
| id | doaj.art-830ce117dbd54d4a8f0e6b9e8f67283a |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-10T06:21:04Z |
| publishDate | 2010-04-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-830ce117dbd54d4a8f0e6b9e8f67283a2022-12-22T01:59:21ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592010-04-0116464765510.3201/eid1604.090107Community-associated Methicillin-Resistant Staphylococcus aureus Strains in Pediatric Intensive Care UnitAaron M. MilstoneKaren C. CarrollTracy RossK. Alexander ShangrawTrish M. PerlVirulent community-associated methicillin-resistant Staphylococcus-aureus (CA-MRSA) strains have spread rapidly in the United States. To characterize the degree to which CA-MRSA strains are imported into and transmitted in pediatric intensive care units (PICU), we performed a retrospective study of children admitted to The Johns Hopkins Hospital PICU, March 1, 2007–May 31, 2008. We found that 72 (6%) of 1,674 PICU patients were colonized with MRSA. MRSA-colonized patients were more likely to be younger (median age 3 years vs. 5 years; p = 0.02) and African American (p<0.001) and to have been hospitalized within 12 months (p<0.001) than were noncolonized patients. MRSA isolates from 66 (92%) colonized patients were fingerprinted; 40 (61%) were genotypically CA-MRSA strains. CA-MRSA strains were isolated from 50% of patients who became colonized with MRSA and caused the only hospital-acquired MRSA catheter-associated bloodstream infection in the cohort. Epidemic CA-MRSA strains are becoming endemic to PICUs, can be transmitted to hospitalized children, and can cause invasive hospital-acquired infections. Further appraisal of MRSA control is needed.https://wwwnc.cdc.gov/eid/article/16/4/09-0107_articlemethicillin resistanceantimicrobial resistanceStaphylococcus aureuspediatric intensive care unitstransmissionepidemiology |
| spellingShingle | Aaron M. Milstone Karen C. Carroll Tracy Ross K. Alexander Shangraw Trish M. Perl Community-associated Methicillin-Resistant Staphylococcus aureus Strains in Pediatric Intensive Care Unit Emerging Infectious Diseases methicillin resistance antimicrobial resistance Staphylococcus aureus pediatric intensive care units transmission epidemiology |
| title | Community-associated Methicillin-Resistant Staphylococcus aureus Strains in Pediatric Intensive Care Unit |
| title_full | Community-associated Methicillin-Resistant Staphylococcus aureus Strains in Pediatric Intensive Care Unit |
| title_fullStr | Community-associated Methicillin-Resistant Staphylococcus aureus Strains in Pediatric Intensive Care Unit |
| title_full_unstemmed | Community-associated Methicillin-Resistant Staphylococcus aureus Strains in Pediatric Intensive Care Unit |
| title_short | Community-associated Methicillin-Resistant Staphylococcus aureus Strains in Pediatric Intensive Care Unit |
| title_sort | community associated methicillin resistant staphylococcus aureus strains in pediatric intensive care unit |
| topic | methicillin resistance antimicrobial resistance Staphylococcus aureus pediatric intensive care units transmission epidemiology |
| url | https://wwwnc.cdc.gov/eid/article/16/4/09-0107_article |
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