The Effectiveness of Digital Health Lifestyle Interventions on People With Prediabetes: Protocol for a Systematic Review, Meta-Analysis, and Meta-Regression
BackgroundThere has been an increasing interest in the use of digital health lifestyle interventions for people with prediabetes, as these interventions may offer a scalable approach to preventing type 2 diabetes. Previous systematic reviews on digital health lifestyle interv...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JMIR Publications
2024-02-01
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| Series: | JMIR Research Protocols |
| Online Access: | https://www.researchprotocols.org/2024/1/e50340 |
| _version_ | 1797319150484324352 |
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| author | Tanja Fredensborg Holm Flemming Witt Udsen Kristine Færch Morten Hasselstrøm Jensen Bernt Johan von Scholten Ole Kristian Hejlesen Stine Hangaard |
| author_facet | Tanja Fredensborg Holm Flemming Witt Udsen Kristine Færch Morten Hasselstrøm Jensen Bernt Johan von Scholten Ole Kristian Hejlesen Stine Hangaard |
| author_sort | Tanja Fredensborg Holm |
| collection | DOAJ |
| description |
BackgroundThere has been an increasing interest in the use of digital health lifestyle interventions for people with prediabetes, as these interventions may offer a scalable approach to preventing type 2 diabetes. Previous systematic reviews on digital health lifestyle interventions for people with prediabetes had limitations, such as a narrow focus on certain types of interventions, a lack of statistical pooling, and no broader subgroup analysis of intervention characteristics. The identified limitations observed in previous systematic reviews substantiate the necessity of conducting a comprehensive review to address these gaps within the field. This will enable a comprehensive understanding of the effectiveness of digital health lifestyle interventions for people with prediabetes.
ObjectiveThe objective of this systematic review, meta-analysis, and meta-regression is to systematically investigate the effectiveness of digital health lifestyle interventions on prediabetes-related outcomes in comparison with any comparator without a digital component among adults with prediabetes.
MethodsThis systematic review will include randomized controlled trials that investigate the effectiveness of digital health lifestyle interventions on adults (aged 18 years or older) with prediabetes and compare the digital interventions with nondigital interventions. The primary outcome will be change in body weight (kg). Secondary outcomes include, among others, change in glycemic status, markers of cardiometabolic health, feasibility outcomes, and incidence of type 2 diabetes. Embase, PubMed, CINAHL, and CENTRAL (Cochrane Central Register of Controlled Trials) will be systematically searched. The data items to be extracted include study characteristics, participant characteristics, intervention characteristics, and relevant outcomes. To estimate the overall effect size, a meta-analysis will be conducted using the mean difference. Additionally, if feasible, meta-regression on study, intervention, and participant characteristics will be performed. The Cochrane risk of bias tool will be applied to assess study quality, and the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach will be used to assess the certainty of evidence.
ResultsThe results are projected to yield an overall estimate of the effectiveness of digital health lifestyle interventions on adults with prediabetes and elucidate the characteristics that contribute to their effectiveness.
ConclusionsThe insights gained from this study may help clarify the potential of digital health lifestyle interventions for people with prediabetes and guide the decision-making regarding future intervention components.
Trial RegistrationPROSPERO CRD42023426919; http://tinyurl.com/d3enrw9j
International Registered Report Identifier (IRRID)PRR1-10.2196/50340 |
| first_indexed | 2024-03-08T04:02:42Z |
| format | Article |
| id | doaj.art-830d824e99ce41c9a0ecde410fc7cdf8 |
| institution | Directory Open Access Journal |
| issn | 1929-0748 |
| language | English |
| last_indexed | 2024-03-08T04:02:42Z |
| publishDate | 2024-02-01 |
| publisher | JMIR Publications |
| record_format | Article |
| series | JMIR Research Protocols |
| spelling | doaj.art-830d824e99ce41c9a0ecde410fc7cdf82024-02-09T13:30:52ZengJMIR PublicationsJMIR Research Protocols1929-07482024-02-0113e5034010.2196/50340The Effectiveness of Digital Health Lifestyle Interventions on People With Prediabetes: Protocol for a Systematic Review, Meta-Analysis, and Meta-RegressionTanja Fredensborg Holmhttps://orcid.org/0009-0007-1725-5922Flemming Witt Udsenhttps://orcid.org/0000-0003-2293-9169Kristine Færchhttps://orcid.org/0000-0002-6127-0448Morten Hasselstrøm Jensenhttps://orcid.org/0000-0002-6649-8644Bernt Johan von Scholtenhttps://orcid.org/0000-0002-1489-0636Ole Kristian Hejlesenhttps://orcid.org/0000-0003-3578-8750Stine Hangaardhttps://orcid.org/0000-0003-0395-3563 BackgroundThere has been an increasing interest in the use of digital health lifestyle interventions for people with prediabetes, as these interventions may offer a scalable approach to preventing type 2 diabetes. Previous systematic reviews on digital health lifestyle interventions for people with prediabetes had limitations, such as a narrow focus on certain types of interventions, a lack of statistical pooling, and no broader subgroup analysis of intervention characteristics. The identified limitations observed in previous systematic reviews substantiate the necessity of conducting a comprehensive review to address these gaps within the field. This will enable a comprehensive understanding of the effectiveness of digital health lifestyle interventions for people with prediabetes. ObjectiveThe objective of this systematic review, meta-analysis, and meta-regression is to systematically investigate the effectiveness of digital health lifestyle interventions on prediabetes-related outcomes in comparison with any comparator without a digital component among adults with prediabetes. MethodsThis systematic review will include randomized controlled trials that investigate the effectiveness of digital health lifestyle interventions on adults (aged 18 years or older) with prediabetes and compare the digital interventions with nondigital interventions. The primary outcome will be change in body weight (kg). Secondary outcomes include, among others, change in glycemic status, markers of cardiometabolic health, feasibility outcomes, and incidence of type 2 diabetes. Embase, PubMed, CINAHL, and CENTRAL (Cochrane Central Register of Controlled Trials) will be systematically searched. The data items to be extracted include study characteristics, participant characteristics, intervention characteristics, and relevant outcomes. To estimate the overall effect size, a meta-analysis will be conducted using the mean difference. Additionally, if feasible, meta-regression on study, intervention, and participant characteristics will be performed. The Cochrane risk of bias tool will be applied to assess study quality, and the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach will be used to assess the certainty of evidence. ResultsThe results are projected to yield an overall estimate of the effectiveness of digital health lifestyle interventions on adults with prediabetes and elucidate the characteristics that contribute to their effectiveness. ConclusionsThe insights gained from this study may help clarify the potential of digital health lifestyle interventions for people with prediabetes and guide the decision-making regarding future intervention components. Trial RegistrationPROSPERO CRD42023426919; http://tinyurl.com/d3enrw9j International Registered Report Identifier (IRRID)PRR1-10.2196/50340https://www.researchprotocols.org/2024/1/e50340 |
| spellingShingle | Tanja Fredensborg Holm Flemming Witt Udsen Kristine Færch Morten Hasselstrøm Jensen Bernt Johan von Scholten Ole Kristian Hejlesen Stine Hangaard The Effectiveness of Digital Health Lifestyle Interventions on People With Prediabetes: Protocol for a Systematic Review, Meta-Analysis, and Meta-Regression JMIR Research Protocols |
| title | The Effectiveness of Digital Health Lifestyle Interventions on People With Prediabetes: Protocol for a Systematic Review, Meta-Analysis, and Meta-Regression |
| title_full | The Effectiveness of Digital Health Lifestyle Interventions on People With Prediabetes: Protocol for a Systematic Review, Meta-Analysis, and Meta-Regression |
| title_fullStr | The Effectiveness of Digital Health Lifestyle Interventions on People With Prediabetes: Protocol for a Systematic Review, Meta-Analysis, and Meta-Regression |
| title_full_unstemmed | The Effectiveness of Digital Health Lifestyle Interventions on People With Prediabetes: Protocol for a Systematic Review, Meta-Analysis, and Meta-Regression |
| title_short | The Effectiveness of Digital Health Lifestyle Interventions on People With Prediabetes: Protocol for a Systematic Review, Meta-Analysis, and Meta-Regression |
| title_sort | effectiveness of digital health lifestyle interventions on people with prediabetes protocol for a systematic review meta analysis and meta regression |
| url | https://www.researchprotocols.org/2024/1/e50340 |
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