Myokines: Do they really exist?
Skeletal muscle has only recently been considered a secretory organ. Muscle-derived proteins are now termed myokines. Until date, about 20 proteins known as cytokines, growth factors, and adipokines have been reported as myokines. However, only a few studies have been able to demonstrate secretion f...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Japanese Society of Physical Fitness and Sports Medicine
2012-08-01
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| Series: | Journal of Physical Fitness and Sports Medicine |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jpfsm/1/1/1_51/_pdf/-char/en |
| _version_ | 1819131919862857728 |
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| author | Yasuko Manabe Shouta Miyatake Mayumi Takagi |
| author_facet | Yasuko Manabe Shouta Miyatake Mayumi Takagi |
| author_sort | Yasuko Manabe |
| collection | DOAJ |
| description | Skeletal muscle has only recently been considered a secretory organ. Muscle-derived proteins are now termed myokines. Until date, about 20 proteins known as cytokines, growth factors, and adipokines have been reported as myokines. However, only a few studies have been able to demonstrate secretion from the skeletal muscle. Furthermore, many reports are still uncertain of whether proteins are secreted from skeletal muscle cells or from the surrounding tissue, because some studies have measured myokine concentration in blood taken from human and animal subjects, which also contains other organ-derived proteins. Secretion of some myokines is promoted by muscle contraction or insulin stimulation, whereas others seem to be constitutively secreted. The mechanisms of action and roles of myokines are also complicated. Some are believed to affect distant organs through endocrine and paracrine mechanisms, while others affect organs through an autocrine mechanism. In this article, we review updates of myokines, including their history. Furthermore, the article discusses the need to re-define myokines in order to avoid possible misunderstandings because of insufficient data. |
| first_indexed | 2024-12-22T09:23:10Z |
| format | Article |
| id | doaj.art-830efac434d740acbe7c79bf0d4fa7c9 |
| institution | Directory Open Access Journal |
| issn | 2186-8131 2186-8123 |
| language | English |
| last_indexed | 2024-12-22T09:23:10Z |
| publishDate | 2012-08-01 |
| publisher | Japanese Society of Physical Fitness and Sports Medicine |
| record_format | Article |
| series | Journal of Physical Fitness and Sports Medicine |
| spelling | doaj.art-830efac434d740acbe7c79bf0d4fa7c92022-12-21T18:31:09ZengJapanese Society of Physical Fitness and Sports MedicineJournal of Physical Fitness and Sports Medicine2186-81312186-81232012-08-0111515810.7600/jpfsm.1.51jpfsmMyokines: Do they really exist?Yasuko Manabe0Shouta Miyatake1Mayumi Takagi2Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan UniversityDepartment of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan UniversityDepartment of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan UniversitySkeletal muscle has only recently been considered a secretory organ. Muscle-derived proteins are now termed myokines. Until date, about 20 proteins known as cytokines, growth factors, and adipokines have been reported as myokines. However, only a few studies have been able to demonstrate secretion from the skeletal muscle. Furthermore, many reports are still uncertain of whether proteins are secreted from skeletal muscle cells or from the surrounding tissue, because some studies have measured myokine concentration in blood taken from human and animal subjects, which also contains other organ-derived proteins. Secretion of some myokines is promoted by muscle contraction or insulin stimulation, whereas others seem to be constitutively secreted. The mechanisms of action and roles of myokines are also complicated. Some are believed to affect distant organs through endocrine and paracrine mechanisms, while others affect organs through an autocrine mechanism. In this article, we review updates of myokines, including their history. Furthermore, the article discusses the need to re-define myokines in order to avoid possible misunderstandings because of insufficient data.https://www.jstage.jst.go.jp/article/jpfsm/1/1/1_51/_pdf/-char/enmyokineskeletal musclesecretioncontractionexercise |
| spellingShingle | Yasuko Manabe Shouta Miyatake Mayumi Takagi Myokines: Do they really exist? Journal of Physical Fitness and Sports Medicine myokine skeletal muscle secretion contraction exercise |
| title | Myokines: Do they really exist? |
| title_full | Myokines: Do they really exist? |
| title_fullStr | Myokines: Do they really exist? |
| title_full_unstemmed | Myokines: Do they really exist? |
| title_short | Myokines: Do they really exist? |
| title_sort | myokines do they really exist |
| topic | myokine skeletal muscle secretion contraction exercise |
| url | https://www.jstage.jst.go.jp/article/jpfsm/1/1/1_51/_pdf/-char/en |
| work_keys_str_mv | AT yasukomanabe myokinesdotheyreallyexist AT shoutamiyatake myokinesdotheyreallyexist AT mayumitakagi myokinesdotheyreallyexist |