Lack of Adipocytes Alters Hematopoiesis in Lipodystrophic Mice

Lack of Adipocytes Alters Hematopoiesis in Lipodystrophic Mice

Adult hematopoiesis takes place in the perivascular zone of the bone cavity, where endothelial cells, mesenchymal stromal/stem cells and their derivatives such as osteoblasts are key components of bone marrow (BM) niches. Defining the contribution of BM adipocytes to the hematopoietic stem cell nich...

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Bibliographic Details
Main Authors: Anne Wilson, He Fu, Mariano Schiffrin, Carine Winkler, Meriem Koufany, Jean-Yves Jouzeau, Nicolas Bonnet, Federica Gilardi, François Renevey, Sanjiv A. Luther, David Moulin, Béatrice Desvergne
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
lipodystrophy
PPARγ null mice
AZIPtg/+ mice
bone marrow adipocytes
hematopoiesis
extramedullary hematopoiesis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02573/full

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