Simultaneous Inhibition of MEK and Hh Signaling Reduces Pancreatic Cancer Metastasis

Simultaneous Inhibition of MEK and Hh Signaling Reduces Pancreatic Cancer Metastasis

Pancreatic cancer, mostly pancreatic ductal adenocarcinoma (PDAC), is one of the most lethal cancer types, with an estimated 44,330 death in 2018 in the US alone. While targeted therapies and immune checkpoint inhibitors have significantly improved treatment options for patients with lung cancer and...

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Bibliographic Details
Main Authors: Dongsheng Gu, Hai Lin, Xiaoli Zhang, Qipeng Fan, Shaoxiong Chen, Safi Shahda, Yunlong Liu, Jie Sun, Jingwu Xie
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Cancers
Subjects:
hedgehog
metastatic niche
pancreatic cancer
Ihh
MEK
Online Access:https://www.mdpi.com/2072-6694/10/11/403

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