Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland
Our previous studies using gene-targeted mouse models of chronic wasting disease (CWD) demonstrated that Norway and North America cervids are infected with distinct prion strains that respond differently to naturally occurring amino acid variation at residue 226 of the prion protein. Here we perfor...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2023-02-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/29/2/22-0882_article |
| _version_ | 1797945125974835200 |
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| author | Julianna L. Sun Sehun Kim Jenna Crowell Bailey K. Webster Emma K. Raisley Diana C. Lowe Jifeng Bian Sirkka-Liisa Korpenfelt Sylvie L. Benestad Glenn C. Telling |
| author_facet | Julianna L. Sun Sehun Kim Jenna Crowell Bailey K. Webster Emma K. Raisley Diana C. Lowe Jifeng Bian Sirkka-Liisa Korpenfelt Sylvie L. Benestad Glenn C. Telling |
| author_sort | Julianna L. Sun |
| collection | DOAJ |
| description |
Our previous studies using gene-targeted mouse models of chronic wasting disease (CWD) demonstrated that Norway and North America cervids are infected with distinct prion strains that respond differently to naturally occurring amino acid variation at residue 226 of the prion protein. Here we performed transmissions in gene-targeted mice to investigate the properties of prions causing newly emergent CWD in moose in Finland. Although CWD prions from Finland and Norway moose had comparable responses to primary structural differences at residue 226, other distinctive criteria, including transmission kinetics, patterns of neuronal degeneration, and conformational features of prions generated in the brains of diseased mice, demonstrated that the strain properties of Finland moose CWD prions are different from those previously characterized in Norway CWD. Our findings add to a growing body of evidence for a diverse portfolio of emergent strains in Nordic countries that are etiologically distinct from the comparatively consistent strain profile of North America CWD.
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| first_indexed | 2024-04-10T20:49:12Z |
| format | Article |
| id | doaj.art-831123ef9c134d55b29112bf630a78f7 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-10T20:49:12Z |
| publishDate | 2023-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-831123ef9c134d55b29112bf630a78f72023-01-23T18:21:51ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592023-02-0129232333210.3201/eid2902.220882Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, FinlandJulianna L. SunSehun KimJenna CrowellBailey K. WebsterEmma K. RaisleyDiana C. LoweJifeng BianSirkka-Liisa KorpenfeltSylvie L. BenestadGlenn C. Telling Our previous studies using gene-targeted mouse models of chronic wasting disease (CWD) demonstrated that Norway and North America cervids are infected with distinct prion strains that respond differently to naturally occurring amino acid variation at residue 226 of the prion protein. Here we performed transmissions in gene-targeted mice to investigate the properties of prions causing newly emergent CWD in moose in Finland. Although CWD prions from Finland and Norway moose had comparable responses to primary structural differences at residue 226, other distinctive criteria, including transmission kinetics, patterns of neuronal degeneration, and conformational features of prions generated in the brains of diseased mice, demonstrated that the strain properties of Finland moose CWD prions are different from those previously characterized in Norway CWD. Our findings add to a growing body of evidence for a diverse portfolio of emergent strains in Nordic countries that are etiologically distinct from the comparatively consistent strain profile of North America CWD. https://wwwnc.cdc.gov/eid/article/29/2/22-0882_articleprionschronic wasting diseaseCWDmoosegene-targetedGt |
| spellingShingle | Julianna L. Sun Sehun Kim Jenna Crowell Bailey K. Webster Emma K. Raisley Diana C. Lowe Jifeng Bian Sirkka-Liisa Korpenfelt Sylvie L. Benestad Glenn C. Telling Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland Emerging Infectious Diseases prions chronic wasting disease CWD moose gene-targeted Gt |
| title | Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland |
| title_full | Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland |
| title_fullStr | Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland |
| title_full_unstemmed | Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland |
| title_short | Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland |
| title_sort | novel prion strain as cause of chronic wasting disease in a moose finland |
| topic | prions chronic wasting disease CWD moose gene-targeted Gt |
| url | https://wwwnc.cdc.gov/eid/article/29/2/22-0882_article |
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