MicroRNA-138 negatively regulates the hypoxia-inducible factor 1α to suppress melanoma growth and metastasis

MicroRNA-138 negatively regulates the hypoxia-inducible factor 1α to suppress melanoma growth and metastasis

Melanoma with rapid progression towards metastasis has become the deadliest form of skin cancer. However, the mechanism of melanoma growth and metastasis is still unclear. Here, we found that miRNA-138 was lowly expressed and hypoxia-inducible factor 1α (HIF1α) was highly expressed in patients’ mela...

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Bibliographic Details
Main Authors: Haijiang Qiu, Fangchao Chen, Minjun Chen
Format: Article
Language:English
Published: The Company of Biologists 2019-08-01
Series:Biology Open
Subjects:
miRNA-138
HIF1α
Melanoma
Proliferation
Invasion
Metastasis
Online Access:http://bio.biologists.org/content/8/8/bio042937

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