Molecular basis of SAP05-mediated ubiquitin-independent proteasomal degradation of transcription factors

Molecular basis of SAP05-mediated ubiquitin-independent proteasomal degradation of transcription factors

Abstract SAP05, a secreted effector by the obligate parasitic bacteria phytoplasma, bridges host SPL and GATA transcription factors (TFs) to the 26 S proteasome subunit RPN10 for ubiquitination-independent degradation. Here, we report the crystal structures of SAP05 in complex with SPL5, GATA18 and...

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Main Authors: Xiaojie Yan, Xinxin Yuan, Jianke Lv, Bing Zhang, Yongle Huang, Qianqian Li, Jinfeng Ma, Yanran Li, Xiaolu Wang, Yao Li, Ying Yu, Quanyan Liu, Tong Liu, Wenyi Mi, Cheng Dong
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45521-7

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