Discovery, development and optimisation of a novel frog antimicrobial peptide with combined mode of action against drug-resistant bacteria

Discovery, development and optimisation of a novel frog antimicrobial peptide with combined mode of action against drug-resistant bacteria

Antimicrobial peptides (AMP) have emerged as promising candidates for addressing the clinical challenges posed by the rapid evolution of antibiotic-resistant microorganisms. Brevinins, a representative frog-derived AMP family, exhibited broad-spectrum antimicrobial activities, attacking great attent...

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Bibliographic Details
Main Authors: Jingkai Wang, Jibo Hu, Wenyuan Pu, Xiaoling Chen, Chengbang Ma, Yangyang Jiang, Tao Wang, Tianbao Chen, Chris Shaw, Mei Zhou, Lei Wang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Antimicrobial peptide
Brevinin-1
Drug-resistant
LPS binding
DNA binding
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037024002952

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http://www.sciencedirect.com/science/article/pii/S2001037024002952

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