Selective Depletion of CREB in Serotonergic Neurons Affects the Upregulation of Brain-Derived Neurotrophic Factor Evoked by Chronic Fluoxetine Treatment

Selective Depletion of CREB in Serotonergic Neurons Affects the Upregulation of Brain-Derived Neurotrophic Factor Evoked by Chronic Fluoxetine Treatment

Neurotrophic factors are regarded as crucial regulatory components in neuronal plasticity and are postulated to play an important role in depression pathology. The abundant expression of brain-derived neurotrophic factor (BDNF) in various brain structures seems to be of particular interest in this c...

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Bibliographic Details
Main Authors: Katarzyna Rafa-Zabłocka, Grzegorz Kreiner, Monika Bagińska, Irena Nalepa
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Neuroscience
Subjects:
BDNF
NTF3
NGF
CREB
CREM
fluoxetine
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00637/full

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