Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma
Central nervous system (CNS) trauma, including traumatic brain injury and spinal cord injury, has a high rate of disability and mortality, and effective treatment is currently lacking. Previous studies have revealed that neural inflammation plays a vital role in CNS trauma. As the initial enzyme in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Neural Regeneration Research |
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| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=2;spage=258;epage=266;aulast= |
| _version_ | 1811342240619954176 |
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| author | Hao-Jie Zhang Yi-Tuo Chen Xin-Li Hu Wan-Ta Cai Xiang-Yang Wang Wen-Fei Ni Kai-Liang Zhou |
| author_facet | Hao-Jie Zhang Yi-Tuo Chen Xin-Li Hu Wan-Ta Cai Xiang-Yang Wang Wen-Fei Ni Kai-Liang Zhou |
| author_sort | Hao-Jie Zhang |
| collection | DOAJ |
| description | Central nervous system (CNS) trauma, including traumatic brain injury and spinal cord injury, has a high rate of disability and mortality, and effective treatment is currently lacking. Previous studies have revealed that neural inflammation plays a vital role in CNS trauma. As the initial enzyme in neuroinflammation, cytosolic phospholipase A2 (cPLA2) can hydrolyze membranous phosphatides at the sn-2 position in a preferential way to release lysophospholipids and ω3-polyunsaturated fatty acid dominated by arachidonic acid, thereby inducing secondary injuries. Although there is substantial fresh knowledge pertaining to cPLA2, in-depth comprehension of how cPLA2 participates in CNS trauma and the potential methods to ameliorate the clinical results after CNS trauma are still insufficient. The present review summarizes the latest understanding of how cPLA2 participates in CNS trauma, highlighting novel findings pertaining to how cPLA2 activation initiates the potential mechanisms specifically, neuroinflammation, lysosome membrane functions, and autophagy activity, that damage the CNS after trauma. Moreover, we focused on testing a variety of drugs capable of inhibiting cPLA2 or the upstream pathway, and we explored how those agents might be utilized as treatments to improve the results following CNS trauma. This review aimed to effectively understand the mechanism of cPLA2 activation and its role in the pathophysiological processes of CNS trauma and provide clarification and a new referential framework for future research. |
| first_indexed | 2024-04-13T19:08:09Z |
| format | Article |
| id | doaj.art-83178f7a0929455b9e657570f1fcc27c |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-13T19:08:09Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-83178f7a0929455b9e657570f1fcc27c2022-12-22T02:33:55ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742023-01-0118225826610.4103/1673-5374.346460Functions and mechanisms of cytosolic phospholipase A2 in central nervous system traumaHao-Jie ZhangYi-Tuo ChenXin-Li HuWan-Ta CaiXiang-Yang WangWen-Fei NiKai-Liang ZhouCentral nervous system (CNS) trauma, including traumatic brain injury and spinal cord injury, has a high rate of disability and mortality, and effective treatment is currently lacking. Previous studies have revealed that neural inflammation plays a vital role in CNS trauma. As the initial enzyme in neuroinflammation, cytosolic phospholipase A2 (cPLA2) can hydrolyze membranous phosphatides at the sn-2 position in a preferential way to release lysophospholipids and ω3-polyunsaturated fatty acid dominated by arachidonic acid, thereby inducing secondary injuries. Although there is substantial fresh knowledge pertaining to cPLA2, in-depth comprehension of how cPLA2 participates in CNS trauma and the potential methods to ameliorate the clinical results after CNS trauma are still insufficient. The present review summarizes the latest understanding of how cPLA2 participates in CNS trauma, highlighting novel findings pertaining to how cPLA2 activation initiates the potential mechanisms specifically, neuroinflammation, lysosome membrane functions, and autophagy activity, that damage the CNS after trauma. Moreover, we focused on testing a variety of drugs capable of inhibiting cPLA2 or the upstream pathway, and we explored how those agents might be utilized as treatments to improve the results following CNS trauma. This review aimed to effectively understand the mechanism of cPLA2 activation and its role in the pathophysiological processes of CNS trauma and provide clarification and a new referential framework for future research.http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=2;spage=258;epage=266;aulast=autophagy; cytosolic phospholipase a2; drugs; lysosome membrane permeability; mitogen-activated protein kinase; neuroinflammation; spinal cord injury; traumatic brain injury |
| spellingShingle | Hao-Jie Zhang Yi-Tuo Chen Xin-Li Hu Wan-Ta Cai Xiang-Yang Wang Wen-Fei Ni Kai-Liang Zhou Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma Neural Regeneration Research autophagy; cytosolic phospholipase a2; drugs; lysosome membrane permeability; mitogen-activated protein kinase; neuroinflammation; spinal cord injury; traumatic brain injury |
| title | Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma |
| title_full | Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma |
| title_fullStr | Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma |
| title_full_unstemmed | Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma |
| title_short | Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma |
| title_sort | functions and mechanisms of cytosolic phospholipase a2 in central nervous system trauma |
| topic | autophagy; cytosolic phospholipase a2; drugs; lysosome membrane permeability; mitogen-activated protein kinase; neuroinflammation; spinal cord injury; traumatic brain injury |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=2;spage=258;epage=266;aulast= |
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