HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity
RIG-I is a critical receptor in the induction of innate immune responses, but mutations in RIG-I can be associated with hyperactive signalling and autoimmune disease. Here Zheng et al. apply HDX-MS approaches to reveal dysregulated checkpoints that result in recognition of self-derived RNA during RI...
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Bibliographic Details
| Main Authors: |
Jie Zheng,
Chen Wang,
Mi Ra Chang,
Swapnil C. Devarkar,
Brandon Schweibenz,
Gogce C. Crynen,
Ruben D. Garcia-Ordonez,
Bruce D. Pascal,
Scott J. Novick,
Smita S. Patel,
Joseph Marcotrigiano,
Patrick R. Griffin |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2018-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-07780-z
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