Oral exposure to Phytomonas serpens attenuates thrombocytopenia and leukopenia during acute infection with Trypanosoma cruzi.

Oral exposure to Phytomonas serpens attenuates thrombocytopenia and leukopenia during acute infection with Trypanosoma cruzi.

Mice infected with Trypanosoma cruzi, the agent of Chagas disease, rapidly develop anemia and thrombocytopenia. These effects are partially promoted by the parasite trans-sialidase (TS), which is shed in the blood and depletes sialic acid from the platelets, inducing accelerated platelet clearance a...

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Main Authors: Rosiane V da Silva, Aparecida D Malvezi, Leonardo da Silva Augusto, Danielle Kian, Vera Lúcia H Tatakihara, Lucy M Yamauchi, Sueli F Yamada-Ogatta, Luiz V Rizzo, Sergio Schenkman, Phileno Pinge-Filho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3699546?pdf=render

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