Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer’s disease

Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer’s disease

Abstract Background Reactive oxidative stress is a critical player in the amyloid beta (Aβ) toxicity that contributes to neurodegeneration in Alzheimer’s disease (AD). Damaged mitochondria are one of the main sources of reactive oxygen species and accumulate in Aβ plaque-associated dystrophic neurit...

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Bibliographic Details
Main Authors: Maria Calvo-Rodriguez, Elizabeth K. Kharitonova, Austin C. Snyder, Steven S. Hou, Maria Virtudes Sanchez-Mico, Sudeshna Das, Zhanyun Fan, Hamid Shirani, K. Peter R. Nilsson, Alberto Serrano-Pozo, Brian J. Bacskai
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Molecular Neurodegeneration
Subjects:
Oxidative stress
ROS
Alzheimer’s disease
Mitochondria
SS31
Neurodegeneration
Online Access:https://doi.org/10.1186/s13024-024-00702-2

Internet

https://doi.org/10.1186/s13024-024-00702-2

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