Ectopic Expression of FVIII in HPCs and MSCs Derived from hiPSCs with Site-Specific Integration of <i>ITGA2B</i> Promoter-Driven <i>BDDF8</i> Gene in Hemophilia A
Hemophilia A (HA) is caused by mutations in the coagulation factor VIII (FVIII) gene <i>(F8)</i>. Gene therapy is a hopeful cure for HA; however, FVIII inhibitors formation hinders its clinical application. Given that platelets promote coagulation via locally releasing α-granule, FVIII e...
Main Authors: | Junya Zhao, Miaojin Zhou, Zujia Wang, Lingqian Wu, Zhiqing Hu, Desheng Liang |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-01-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/23/2/623 |
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